• Publications
  • Influence
Interleukin-1 beta inhibits long-term potentiation in the CA3 region of mouse hippocampal slices.
The effect of recombinant human interleukin 1-beta (IL-1 beta) on long-term potentiation (LTP) in the mossy fiber-CA3 pathway of mouse hippocampal slice preparations was investigated. IL-1 betaExpand
  • 314
  • 12
Novel antioxidative metabolites in rat liver with ingested sesamin.
Sesamin, a major lignan in sesame oil, is known to have many biological activities, especially protective effects against oxidative damage in the liver. As sesamin itself has no antioxidativeExpand
  • 166
  • 10
Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro.
Fifty-four polyphenols isolated from tea leaves were evaluated for their inhibitory activities against pancreatic lipase, the key enzyme of lipid absorption in the gut. (-)-EpigallocatechinExpand
  • 119
  • 10
Antihypertensive Effect of Angiotensin I-Converting Enzyme Inhibitory Peptides from a Sesame Protein Hydrolysate in Spontaneously Hypertensive Rats
Sesame peptide powder (SPP) exhibited angiotensin I-converting enzyme (ACE) inhibitory activity, and significantly and temporarily decreased the systolic blood pressure (SBP) in spontaneouslyExpand
  • 88
  • 7
Aging of whiskey increases 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity.
1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of Japanese whiskey after various aging periods in oak barrels was measured to evaluate the antioxidative effects of whiskey. TheExpand
  • 115
  • 6
Identification of the major antioxidative metabolites in biological fluids of the rat with ingested (+)-catechin and (-)-epicatechin.
  • M. Harada, Y. Kan, +5 authors Y. Kiso
  • Medicine, Chemistry
  • Bioscience, biotechnology, and biochemistry
  • 23 June 1999
(+)-Catechin and (-)-epicatechin are known to be biologically effective antioxidants present in the human diet, particularly in wine and tea. We studied the metabolism of these compounds to elucidateExpand
  • 146
  • 5
Possible Role of L-Carnosine in the Regulation of Blood Glucose through Controlling Autonomic Nerves
Mammalian muscles synthesize L-carnosine, but its roles were unknown. Previously, we found in rats that the administration of a certain amount of L-carnosine elicited an inhibition of theExpand
  • 101
  • 5
Dose-dependent effects of L-carnosine on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats.
The physiological function of L-carnosine (beta-alanyl-L-histidine) synthesized in mammalian muscles has been unclear. Previously, we observed that intravenous (i.v.) injection of L-carnosineExpand
  • 66
  • 5
  • PDF
Antiallergic Effects of Lactobacillus pentosus Strain S-PT84 Mediated by Modulation of Th1/Th2 Immunobalance and Induction of IL-10 Production
Background: Many types of fermented food are consumed in Japan. Although some are produced by plant-origin lactic-acid bacteria (LAB) fermentation, the physiological functions of such bacteria remainExpand
  • 110
  • 5
Sesamin Metabolites Induce an Endothelial Nitric Oxide-Dependent Vasorelaxation through Their Antioxidative Property-Independent Mechanisms: Possible Involvement of the Metabolites in the
Sesamin, a major lignan in sesame seeds and oil, has been known to lower blood pressure in several types of experimental hypertensive animals. A recent study demonstrated that sesamin metabolites hadExpand
  • 78
  • 4
  • PDF