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Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R/IL12RB2 regions associated with Behçet's disease
TLDR
The known association of Behçet's disease with HLA-B*51 was confirmed and a second, independent association within the MHC Class I region was identified and the disease-associated IL10 variant was associated with diminished mRNA expression and low protein production. Expand
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1
TLDR
A genome-wide association study of 779,465 SNPs with imputed genotypes in 1,209 Turkish individuals with Behçet's disease and 1,278 controls found new associations at CCR1, STAT4 and KLRC4, and found evidence for interaction between HLA-B*51 and ERAP1. Expand
Arginine methylation of Piwi proteins, catalyzed by dPRMT5, is required for Ago3 and Aub stability
TLDR
It is reported that Piwi family proteins of mouse, Xenopus laevis and Drosophila contain symmetrical dimethylarginines (sDMAs) and suggested an interacting pathway of genes that are required for piRNA function and PGC specification. Expand
Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease.
TLDR
It is concluded that the UUG codon-specific translational defect of the mutant mt tRNAs(Leu(UUR)) is the primary cause of MELAS at the molecular level. Expand
Mili and Miwi target RNA repertoire reveals piRNA biogenesis and function of Miwi in spermiogenesis
TLDR
The in vivo pathway of primary piRNA biogenesis is reported and implicate distinct nucleolytic activities that process Piwi-bound precursor transcripts that indicate that pachytene piRNAs are the end products of RNA processing. Expand
Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers
TLDR
A novel type of transfer RNA (tRNA)-derived small RNA, termed Sex HOrmone-dependent TRNA-derived RNAs (SHOT-RNAs), are specifically and abundantly expressed in estrogen receptor (ER)-positive breast cancer and androgen receptor (AR)-positive prostate cancer cell lines. Expand
Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs
TLDR
The findings suggest that the repertoire of human miRNAs is far more extensive than currently represented by public repositories and that there is a significant number of lineage- and/or tissue-specific mi RNAs that are uncharacterized. Expand
Biosynthesis of wybutosine, a hyper‐modified nucleoside in eukaryotic phenylalanine tRNA
TLDR
To identify genes responsible for yW synthesis from uncharacterized genes of Saccharomyces cerevisiae, a systematic reverse genetic approach combined with mass spectrometry (‘ribonucleome analysis’) revealed its sequential biosynthetic pathway. Expand
Mouse Piwi-interacting RNAs are 2′-O-methylated at their 3′ termini
TLDR
It is reported that the 3′ termini of PiRNAs are 2′-O-methylated; this modification may have important implications for the biogenesis and function of piRNAs. Expand
Arginine methylation of Aubergine mediates Tudor binding and germ plasm localization.
TLDR
The findings indicate that germ plasm assembly requires sDMA modification of Aub by dPRMT5, which, in turn, is required for binding to Tudor, and suggests that the function of the piRNA pathway in PGC specification may be independent of its role in transposon control. Expand
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