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Alteration by p11 of mGluR5 localization regulates depression-like behaviors
TLDR
It is reported that p11 can also regulate depression-like behaviors via regulation of a glutamatergic receptor in mice, and the molecular and cellular basis by which mGluR5 antagonism achieves its antidepressant-like activity is identified. Expand
p11 regulates the surface localization of mGluR5
TLDR
A dramatic redistribution of endogenous p11 from the cytoplasm to the plasma membrane was observed in human embryonic kidney 293 (HEK293) cells transfected with wild-type mGluR5 and with the mutant form of mGLUR5, which cannot bind to p11, p11 was partially present in the membrane but a significant portion remained in the cy toplasm. Expand