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The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells.
- Tony Gutschner, Monika Haemmerle, +11 authors S. Diederichs
- Biology, Medicine
- Cancer research
- 1 February 2013
The long noncoding RNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), also known as MALAT-1 or NEAT2 (nuclear-enriched abundant transcript 2), is a highly conserved nuclear… Expand
Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss.
Genome-wide analyses have identified thousands of long noncoding RNAs (lncRNAs). Malat1 (metastasis-associated lung adenocarcinoma transcript 1) is among the most abundant lncRNAs whose expression is… Expand
Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells.
- Y. Kim, J. W. Yoon, X. Xiao, N. Dean, B. Monia, E. Marcusson
- Medicine, Biology
- Cancer research
- 15 April 2007
The sonic hedgehog (Shh) pathway contributes to the initiation and progression of tumors with various origins when aberrantly activated. In this study, we investigated if the Shh pathway is important… Expand
Inhibition of NF-κB by ginsenoside Rg3 enhances the susceptibility of colon cancer cells to docetaxel
Ginsenoside Rg3, the main constituent isolated from Panax ginseng, has been of interest for use as a cancer preventive or therapeutic agent. We investigated here whether Rg3 can inhibit the activity… Expand
Technological Capabilities and Samsung Electronics' International Production Network in Asia
- Y. Kim
- Engineering, Economics
- 1 November 1997
Technological Capabilities and Samsung Electronics' International Production Network in Asia Youngsoo Kim Working Paper 106 November 1997 ©Copyright 1997, BRIE Youngsoo Kim is a Visiting Fellow at… Expand
Inhibition of Growth and Metastasis of Human Hepatocellular Carcinoma by Antisense Oligonucleotide Targeting Signal Transducer and Activator of Transcription 3
Purpose: Hepatocellular carcinoma (HCC) is an aggressive malignancy and is a devastating clinical complication of chronic liver disease. Therapeutic options are limited mainly because the genetic and… Expand
Identification of novel PPARgamma target genes in primary human adipocytes.
Adipogenesis is the process by which undifferentiated precursor cells differentiate into fat laden adipocytes. The nuclear proteins peroxisome proliferator-activated receptors (PPARs) play a central… Expand
Activation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate Cancer.
The androgen receptor (AR) is required for castration-resistant prostate cancer (CRPC) progression, but the function and disease relevance of AR-bound enhancers remain unclear. Here, we identify a… Expand
GLI2 Knockdown Using an Antisense Oligonucleotide Induces Apoptosis and Chemosensitizes Cells to Paclitaxel in Androgen-Independent Prostate Cancer
Purpose: GLI transcription factors mediate hedgehog signaling and have been implicated in several human malignancies, including prostate cancer. The objectives of this study were to characterize GLI2… Expand
Assessment of Human Health Risk of Dioxin in Korea
- Youngwook Lim, Jiyeon Yang, Y. Kim, Yoonseok Chang, D. Shin
- Chemistry, Medicine
- Environmental monitoring and assessment
- 1 March 2004
This study assessed the daily exposure to dioxin using comparable approach methods in order to predict the human health risks of dioxin on the general adult population and incinerator workers in… Expand