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Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses
ABSTRACT Phylogenetic analysis has demonstrated that some positive-sense RNA viruses can be classified into the picornavirus-like supercluster, which includes picornaviruses, caliciviruses, andExpand
Comparative effects of high dietary levels of organic and inorganic selenium on selenium toxicity of growing-finishing pigs.
  • Y. Kim, D. Mahan
  • Chemistry, Medicine
  • Journal of animal science
  • 1 April 2001
This experiment evaluated the effect of high dietary Se levels using organic or inorganic Se on the selenosis responses in growing-finishing swine. A 2 x 4 factorial arrangement of treatments in aExpand
Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor
Coronaviruses infect animals and humans causing a wide range of diseases. The diversity of coronaviruses in many mammalian species is contributed by relatively high mutation and recombination ratesExpand
Bile acids are essential for porcine enteric calicivirus replication in association with down-regulation of signal transducer and activator of transcription 1.
A porcine enteric calicivirus (PEC), strain Cowden in the family Caliciviridae (genus Sapovirus), can be propagated in a continuous cell line, LLC-PK cells, but only in the presence of an intestinalExpand
The Effects of Simvastatin or Interferon-α on Infectivity of Human Norovirus Using a Gnotobiotic Pig Model for the Study of Antivirals
The lack of an animal model for human norovirus (HuNoV) has hindered the development of therapeutic strategies. This study demonstrated that a commonly used cholesterol-lowering statin medication,Expand
Inhibition of influenza virus replication by plant-derived isoquercetin.
Influenza virus infects the respiratory system of human and animals causing mild to severe illness which could lead to death. Although vaccines are available, there is still a great need forExpand
Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis
Objectives The safety and efficacy of the 3C-like protease inhibitor GC376 was tested on a cohort of client-owned cats with various forms of feline infectious peritonitis (FIP). Methods Twenty catsExpand
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element
Abstract There are currently no approved vaccines or small molecule therapeutics available for the prophylaxis or treatment of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infections.Expand
Production of hybrid double- or triple-layered virus-like particles of group A and C rotaviruses using a baculovirus expression system.
Dual infections by group A and group C rotaviruses have been reported, but no reassortants between group A and group C rotaviruses have been described. The VP6 major inner capsid protein of group AExpand
Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease.
The first series of peptidyl aldehyde inhibitors that incorporate in their structure a glutamine surrogate has been designed and synthesized based on the known substrate specificity of Norwalk virusExpand