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Genomic scans for selective sweeps using SNP data.
- R. Nielsen, Scott H. Williamson, Y. Kim, M. Hubisz, A. Clark, C. Bustamante
- Medicine, Biology
- Genome research
- 1 November 2005
Detecting selective sweeps from genomic SNP data is complicated by the intricate ascertainment schemes used to discover SNPs, and by the confounding influence of the underlying complex demographics… Expand
Detecting a local signature of genetic hitchhiking along a recombining chromosome.
The theory of genetic hitchhiking predicts that the level of genetic variation is greatly reduced at the site of strong directional selection and increases as the recombinational distance from the… Expand
Linkage Disequilibrium as a Signature of Selective Sweeps
The hitchhiking effect of a beneficial mutation, or a selective sweep, generates a unique distribution of allele frequencies and spatial distribution of polymorphic sites. A composite-likelihood test… Expand
Distinguishing Between Selective Sweeps and Demography Using DNA Polymorphism Data
In 2002 Kim and Stephan proposed a promising composite-likelihood method for localizing and estimating the fitness advantage of a recently fixed beneficial mutation. Here, we demonstrate that their… Expand
Pattern of polymorphism after strong artificial selection in a domestication event.
The process of strong artificial selection during a domestication event is modeled, and its effect on the pattern of DNA polymorphism is investigated. The model also considers population bottleneck… Expand
Joint effects of genetic hitchhiking and background selection on neutral variation.
Due to relatively high rates of strongly selected deleterious mutations, directional selection on favorable alleles (causing hitchhiking effects on linked neutral polymorphisms) is expected to occur… Expand
Spread of an inactive form of caspase-12 in humans is due to recent positive selection.
- Y. Xue, A. Daly, +11 authors C. Tyler-Smith
- Biology, Medicine
- American journal of human genetics
- 1 April 2006
The human caspase-12 gene is polymorphic for the presence or absence of a stop codon, which results in the occurrence of both active (ancestral) and inactive (derived) forms of the gene in the… Expand
An adaptive hypothesis for the evolution of the Y chromosome.
Population geneticists remain unsure of the forces driving the evolution of Y chromosomes. Here we consider the possibility that the degeneration of the Y reflects its inability to evolve adaptively.… Expand
A Pseudohitchhiking Model of X vs. Autosomal Diversity
We study levels of X-linked vs. autosomal diversity using a model developed to analyze the hitchhiking effect. Repeated bouts of hitchhiking are thought to lower X-linked diversity for two reasons:… Expand
Allele Frequency Distribution Under Recurrent Selective Sweeps
- Y. Kim
- Biology, Medicine
- 1 March 2006
The allele frequency of a neutral variant in a population is pushed either upward or downward by directional selection on a linked beneficial mutation (“selective sweeps”). DNA sequences sampled… Expand