• Publications
  • Influence
Genomic scans for selective sweeps using SNP data.
Detecting selective sweeps from genomic SNP data is complicated by the intricate ascertainment schemes used to discover SNPs, and by the confounding influence of the underlying complex demographicsExpand
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Detecting a local signature of genetic hitchhiking along a recombining chromosome.
The theory of genetic hitchhiking predicts that the level of genetic variation is greatly reduced at the site of strong directional selection and increases as the recombinational distance from theExpand
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Linkage Disequilibrium as a Signature of Selective Sweeps
The hitchhiking effect of a beneficial mutation, or a selective sweep, generates a unique distribution of allele frequencies and spatial distribution of polymorphic sites. A composite-likelihood testExpand
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Distinguishing Between Selective Sweeps and Demography Using DNA Polymorphism Data
In 2002 Kim and Stephan proposed a promising composite-likelihood method for localizing and estimating the fitness advantage of a recently fixed beneficial mutation. Here, we demonstrate that theirExpand
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Pattern of polymorphism after strong artificial selection in a domestication event.
  • H. Innan, Y. Kim
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 20 July 2004
The process of strong artificial selection during a domestication event is modeled, and its effect on the pattern of DNA polymorphism is investigated. The model also considers population bottleneckExpand
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Joint effects of genetic hitchhiking and background selection on neutral variation.
Due to relatively high rates of strongly selected deleterious mutations, directional selection on favorable alleles (causing hitchhiking effects on linked neutral polymorphisms) is expected to occurExpand
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Spread of an inactive form of caspase-12 in humans is due to recent positive selection.
The human caspase-12 gene is polymorphic for the presence or absence of a stop codon, which results in the occurrence of both active (ancestral) and inactive (derived) forms of the gene in theExpand
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An adaptive hypothesis for the evolution of the Y chromosome.
Population geneticists remain unsure of the forces driving the evolution of Y chromosomes. Here we consider the possibility that the degeneration of the Y reflects its inability to evolve adaptively.Expand
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Allele Frequency Distribution Under Recurrent Selective Sweeps
  • Y. Kim
  • Biology, Medicine
  • Genetics
  • 1 March 2006
The allele frequency of a neutral variant in a population is pushed either upward or downward by directional selection on a linked beneficial mutation (“selective sweeps”). DNA sequences sampledExpand
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A Pseudohitchhiking Model of X vs. Autosomal Diversity
We study levels of X-linked vs. autosomal diversity using a model developed to analyze the hitchhiking effect. Repeated bouts of hitchhiking are thought to lower X-linked diversity for two reasons:Expand
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