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Joint effects of genetic hitchhiking and background selection on neutral variation.
Generalization of these results to a more appropriate multilocus model suggests that, in regions of very low recombination rates, stationary levels of nucleotide diversity are primarily determined by hitchhiking, whereas in areas of high recombination, background selection is the dominant force.
An adaptive hypothesis for the evolution of the Y chromosome.
The possibility that the degeneration of the Y reflects its inability to evolve adaptively is considered, which can explain the evolution of Y chromosomes in taxa such as Drosophila that have very large population sizes.
Inferring natural selection on fine-scale chromatin organization in yeast.
This work investigates the idea that the functional conservation of regulatory regions should be associated with the conservation of sequence-dependent bending properties of DNA that determine its affinity for the nucleosome, and demonstrates that different patterns of chromatin evolution have shaped DNA-nucleosome interaction at the core promoters of TATA-containing and Tata-less genes.
The Molecular Evolution of Nucleosome Positioning Through Sequence-Dependent Deformation of the DNA Polymer
It is demonstrated that natural selection may act independently on different DNA sequence properties responsible for local chromatin organization, and at least with respect to the deformation energy of the DNA molecule in the nucleosome, the presence of the genetic code has greatly restricted the ability of sequences to evolve the dynamic nucleosomes organization typically observed in promoter regions.
Persistence of microsatellite arrays in finite populations.
For all three models, it was found that persistence time of microsatellite loci increases with population size in a sublinear fashion, which suggests that the approximately 30% deficiency on chromosome X (relative to autosomes) cannot be explained by the fact that the X chromosome has a smaller effective population size than do autosomes.
Predicted role of particular phonons in the strand separation melting of the DNA double helix.
The frequency-dependent vibrational fluctuation of the hydrogen bonds around a nucleation defect for the strand separation melting of a DNA polymer poly(dG)-poly(dC) is studied using a modified…