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Differential effects of ascorbate depletion and alpha,alpha'-dipyridyl treatment on the stability, but not on the secretion, of type IV collagen in differentiated F9 cells.
TLDR
It is indicated that partial hydroxylation of type IV collagen confers sufficient helical structure to allow interchain disulfide bond formation and resistance to pepsin and intracellular degradation, but not sufficient for optimal secretion. Expand