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An IL‐27/Stat3 axis induces expression of programmed cell death 1 ligands (PD‐L1/2) on infiltrating macrophages in lymphoma
TLDR
It is found that macrophages in lymphoma tissues of almost all cases of adult T‐cell leukemia/lymphoma, follicular lymphoma and diffuse large B‐cell lymphoma expressed PD‐L1, and an IL‐27‐Stat3 axis might be a target for immunotherapy for lymphoma patients. Expand
Clarithromycin attenuates autophagy in myeloma cells.
TLDR
CAM may halt the autophagy process after fusion of autophagosomes with lysosomes, which may explain how CAM, combined with thalidomide, augments the cytotoxic effects of the latter on MM cells and suggests that modification of Autophagy might represent a new approach for therapy of MM. Expand
Hypoxia reduces CD138 expression and induces an immature and stem cell-like transcriptional program in myeloma cells
TLDR
The present data suggest that a hypoxic microenvironment affects the phenotype of MM cells, which may correlate with disease progression, and it is proposed that hypoxia induces immature and stem cell-like transcription phenotypes in myeloma cells. Expand
Induction of cell cycle arrest and apoptosis in myeloma cells by cepharanthine, a biscoclaurine alkaloid.
TLDR
Data show, for the first time, that CEP has anti-myeloma effects by the activation of apoptotic pathways and blocking cell cycle progression via CDK inhibitors. Expand
Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells
TLDR
The present data show for the first time that SHK induces cell death in MM cells, and support the use of SHK as a potential therapeutic agent for MM. Expand
Lactate, a putative survival factor for myeloma cells, is incorporated by myeloma cells through monocarboxylate transporters 1
TLDR
The present data suggest that lactate is produced by multiple myeloma cell lines and stromal cells, and contributes to the survival of such MM cells in autocrine or paracrine manners. Expand
Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement
TLDR
Positron emission tomography/computed tomography and genetic study are useful for the diagnosis, and allo-HSCT achieved complete remission in this patient. Expand
Successful Treatment of Bing-Neel Syndrome Accompanying Waldenström's Macroglobulinemia with R-MPV: A Case Report.
TLDR
A 60-year-old woman with bed-bound polyneuropathy, edema, splenomegaly, IgM-λ-type monoclonal protein and CD20-positive lymphocyte infiltration in the bone marrow resolved her neurological symptoms in association with reduction of IgM levels to 367 mg/dL. Expand
Lactate Is a Crucial Energy Source For Multiple Myeloma (MM) Cells In Bone Marrow Microenvironment
TLDR
The results suggest that the growth of MM cells, at least in part, depends on lactate under a normoxic condition, and suggest that lactate may play a role as an energy interplay shuttle between stromal cells and MM cells. Expand
Rapid amelioration of hyperglycemia facilitated by dasatinib in a chronic myeloid leukemia patient with type 2 diabetes mellitus.
TLDR
The case of a 57-year-old diabetic CML patient who was resistant to imatinib and initially required 20 units of insulin daily to control his blood glucose levels, after the initiation of dasatinib, the patient's insulin requirements declined rapidly and insulin treatment was discontinued within two weeks, suggesting that dAsatinib facilitated the recovery of insulin production. Expand
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