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HIV Infection Linked to Injection Use of Oxymorphone in Indiana, 2014-2015.
TLDR
Injection-drug use of extended-release oxymorphone within a network of persons who inject drugs in Indiana led to the introduction and rapid transmission of HIV. Expand
Hepatitis A virus: host interactions, molecular epidemiology and evolution.
TLDR
Up-to-date information on the HAV molecular epidemiology and evolution is presented, and the most relevant features of the Hav-host interactions are highlighted. Expand
Serological diagnostics of hepatitis E virus infection.
TLDR
Development of antigens specially designed for the identification of serological markers specific to acute infection and of IgG anti-HEV specific to the convalescent phase of infection would greatly facilitate accurate identification of active, recent and past HEV infections. Expand
The Hepatitis E Virus Polyproline Region Is Involved in Viral Adaptation
TLDR
Although the polyproline region appears to be hypervariable and homoplastic, it retains as much phylogenetic signal as any other similar sized region in the ORF1, indicating that convergent evolution operates within the major HEV phylogenetic lineages. Expand
Outbreak of hepatitis A in the USA associated with frozen pomegranate arils imported from Turkey: an epidemiological case study.
TLDR
Imported frozen pomegranate arils were identified as the vehicle early in the investigation by combining epidemiology--with data from several sources--genetic analysis of patient samples, and product tracing, and postexposure prophylaxis can successfully prevent hepatitis A illness when a specific product is identified. Expand
Evolutionary History and Population Dynamics of Hepatitis E Virus
TLDR
HEV appears to have evolved through a series of steps, in which the ancestors of HEV may have adapted to a succession of animal hosts leading to humans, and a substantial temporal variation in the rate of transmission among HEV genotypes in different geographic regions late in the 20th Century. Expand
A Novel Hepacivirus with an Unusually Long and Intrinsically Disordered NS5A Protein in a Wild Old World Primate
TLDR
The discovery of a novel and highly divergent GBV-B-like virus in an Old World monkey, the black-and-white colobus (Colobus guereza), in Uganda sheds new light on the natural history and evolution of the hepaciviruses and on the extent of structural variation within the Flaviviridae. Expand
Coordinated evolution of the hepatitis C virus
TLDR
It is shown that, despite its extensive heterogeneity, the evolution of hepatitis C virus is primarily shaped by negative selection and that numerous coordinated substitutions in the polyprotein can be organized into a scale-free network whose degree of connections between sites follows a power-law distribution. Expand
Hepatitis C virus infections from unsafe injection practices at an endoscopy clinic in Las Vegas, Nevada, 2007-2008.
TLDR
This investigation highlighted breaches in aseptic technique, deficiencies in oversight of outpatient settings, and difficulties in detecting and investigating such outbreaks of hepatitis C virus (HCV) in Nevada. Expand
Temporal Variations in the Hepatitis C Virus Intrahost Population during Chronic Infection
TLDR
Intrahost HCV evolution in all four patients was characterized by a consistent increase in negative selection over time, suggesting the increasing HCV adaptation to the host late in infection. Expand
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