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Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers
TLDR
Tuberculosis and sarcoidosis revealed similar blood transcriptional profiles, dominated by interferon-inducible transcripts, while pneumonia and lung cancer showed distinct signatures,dominated by inflammatory genes.
Phenotypes of organ involvement in sarcoidosis
TLDR
Five new clinical phenotypes of sarcoidosis have been identified by analysing organ manifestations of 1932 patients and will be useful to recruit homogenous cohorts in future biomedical studies.
High levels of virus-specific CD4+ T cells predict severe pandemic influenza A virus infection.
TLDR
High levels of circulating virus-specific CD4(+) T cells to two viral internal proteins (nucleoprotein and matrix) in the first phase of infection are associated with subsequent development of severe IAV infection.
CTAS: a CT score to quantify disease activity in pulmonary sarcoidosis
TLDR
CTAS provides a concept for an objective and reproducible CT scoring method to quantify disease activity in sarcoidosis and can potentially be used to stratify patients according to disease activity, determine response to treatment and establish if fibrotic sarcoidsosis is active.
Abnormalities in iNKT cells are associated with impaired ability of monocytes to produce IL‐10 and suppress T‐cell proliferation in sarcoidosis
TLDR
It is suggested that reduced iNKT‐cell numbers in sarcoidosis may lead to impaired monocytic IL‐10 production and unchecked T‐cell expansion in sarCOidosis, and interaction between i NKT cells and monocytes could be restored following their coculture with iN KT cells, in a CD1d‐ and cell contact‐dependent process.
Peer review correspondence
My apologies for the slight delay in processing the review of your manuscript ID eji.201344284 entitled "Impaired monocytic IL-10 production in sarcoidosis and potential link to abnormalities in iNKT
A Combination Score Of Raised Sace, Lymphopenia And Hypergammaglobulinemia Correlates With Active Disease On Thoracic CT Scan Of Patients With Pulmonary Sarcoidosis
TLDR
The concurrent treatment arm in SOCCAR ranks top in survival with comparable toxicity and quality of Life is recognised as being of major relevance internationally and are the basis of a proposed multi-centre international study.
Transcriptomic approach to understanding and characterising disease pathogenesis in sarcoidosis
TLDR
After phenotyping patients with active disease into those with and without fibrosis, differential gene expression showed enrichment of immune related gene sets in the fibrotic cohort, and highlighted the roles of several significantly upregulated genes including CCL19, CCL7, CXCR3, CCR2, ADAMDEC1 and MMP12 in the pathogenesis of fibrotIC sarcoidosis.
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