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Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Stargazer, an ataxic and epileptic mutant mouse, lacks functional AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate) receptors on cerebellar granule cells. Stargazin, the mutated protein,Expand
Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins
Functional expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in cerebellar granule cells requires stargazin, a member of a large family of four-pass transmembraneExpand
Postsynaptic Targeting of Alternative Postsynaptic Density-95 Isoforms by Distinct Mechanisms
Members of the postsynaptic density-95 (PSD95)/synapse-associated protein-90 (SAP90) family of scaffolding proteins contain a common set of modular protein interaction motifs including PDZExpand
AMPA Receptor Synaptic Targeting Regulated by Stargazin Interactions with the Golgi-Resident PDZ Protein nPIST
Regulation of AMPA receptors (AMPARs) at synapses plays a critical role in alterations of synaptic strength in the brain. Stargazin, an AMPAR-interacting protein, is critical for clustering andExpand
Contrasting Localizations of MALS/LIN-7 PDZ Proteins in Brain and Molecular Compensation in Knockout Mice*
Proteins containing PDZ (postsynaptic density-95, discs large, zonula occludens) domains play a general role in recruiting receptors and enzymes to specific synaptic sites. In Caenorhabditis elegans,Expand
The effect of nitric oxide synthase inhibitor on form-deprivation myopia.
PURPOSE Form-deprivation myopia (FDM) is believed to result principally from actions of substances that modulate information processing in the retina. We used a chick model to investigate what roleExpand
Retinal function with lens-induced myopia compared with form-deprivation myopia in chicks
Abstract• Background: The retina is known to be involved in the development of form-deprivation myopia (FDM); however, it is not clear whether the retinal changes that lead to lens-induced myopiaExpand
Retinal glial cells stimulate microvascular pericyte proliferation via fibroblast growth factor and platelet-derived growth factor in vitro.
PURPOSE To investigate whether retinal glial cells (RGCs), which are believed to play an important role in the development and maintenance of microvessels, stimulate the proliferation of retinalExpand
Effect of a Nitric Oxide Synthase Inhibitor on Lens-Induced Myopia
Purpose: It has still not been determined whether the retinal mechanism causing form-deprivation myopia (FDM) is different from that causing lens-induced myopia (LIM). We previously reported that FDMExpand
The Effect of Nitric Oxide on the Contractile Tone of Müller Cells
The effect of nitric oxide (NO) on the contractile tone of Müller cells was investigated. Müller cells, isolated from the retina of chick embryos, were cultured on thin sheets of silicone.Expand
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