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Expression of cyclooxygenase-1 and -2 in human colorectal cancer.
Several studies indicate that nonsteroidal anti-inflammatory drugs including indomethacin, aspirin, sulindac, and piroxicam reduce the risk of colon cancer. Furthermore, nonsteroidal… Expand
Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease.
- M. Hamaguchi, T. Kojima, +10 authors T. Yoshikawa
- World journal of gastroenterology
- 14 March 2007
AIM To clarify whether nonalcoholic fatty liver disease (NAFLD) increases the risk of cardiovascular disease. METHODS We carried out a prospective observational study with a total of 1637… Expand
The Severity of Ultrasonographic Findings in Nonalcoholic Fatty Liver Disease Reflects the Metabolic Syndrome and Visceral Fat Accumulation
- M. Hamaguchi, T. Kojima, +10 authors T. Okanoue
- The American Journal of Gastroenterology
- 1 December 2007
BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is closely associated with the metabolic syndrome.AIM:We evaluated the association among the metabolic syndrome, visceral fat accumulation, and the… Expand
Peroxisome proliferator-activated receptors (PPARs) are members for the nuclear hormone receptors superfamily of ligand-activated transcriptional factors. PPARs have diverse function for keeping… Expand
ABCB1 C3435T polymorphism influences methotrexate sensitivity in rheumatoid arthritis patients.
- R. Takatori, K. Takahashi, +10 authors T. Kubo
- Clinical and experimental rheumatology
- 1 September 2006
OBJECTIVE Methotrexate (MTX) is most widely used for the treatment of rheumatoid arthritis (RA). However, it has certain drawbacks with regard to individual differences in its therapeutic effects as… Expand
Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2.
- Y. Tsubouchi, Y. Kawahito, M. Kohno, K. Inoue, T. Hla, H. Sano
- Biology, Medicine
- Biochemical and biophysical research…
- 18 May 2001
Rheumatoid arthritis (RA) is a chronic polyarticular joint disease associated with massive synovial proliferation, inflammation, and angiogenesis. PPAR-gamma ligands, both… Expand
Telmisartan is a potent target for prevention and treatment in human prostate cancer.
Angiotensin II receptor blockers (ARBs) are widely used as hypertensive therapeutic agent. Recent studies have reported that ARBs have the potential to inhibit the growth of prostate cancer (PC)… Expand
15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats.
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily and have a dominant regulatory role in adipocyte and monocyte differentiation. PPAR-gamma… Expand
Myeloid-Derived Suppressor Cells Play Crucial Roles in the Regulation of Mouse Collagen-Induced Arthritis
- W. Fujii, E. Ashihara, +10 authors Y. Kawahito
- Biology, Medicine
- The Journal of Immunology
- 1 August 2013
Myeloid-derived suppressor cells (MDSCs) are of myeloid origin and are able to suppress T cell responses. The role of MDSCs in autoimmune diseases remains controversial, and little is known about the… Expand
A Critical Role for Allograft Inflammatory Factor-1 in the Pathogenesis of Rheumatoid Arthritis
Rheumatoid arthritis (RA) is characterized by massive synovial proliferation, angiogenesis, subintimal infiltration of inflammatory cells and the production of cytokines such as TNF-α and IL-6.… Expand