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Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease.
- M. Hamaguchi, T. Kojima, +10 authors T. Yoshikawa
- World journal of gastroenterology
- 14 March 2007
NAFLD is a strong predictor of cardiovascular disease and may play a central role in the cardiovascular risk of MS, and simultaneous inclusion of NAFLD and MS in a multivariate model revealed that NA FLD but not MS retained a statistically significant correlation with cardiovascular disease. Expand
Expression of cyclooxygenase-1 and -2 in human colorectal cancer.
The data suggest that the enhanced expression of the COX-2 gene in Colon cancer tissues may contribute to the enhanced synthesis of prostaglandin E2 by the colon cancer tissues. Expand
The Severity of Ultrasonographic Findings in Nonalcoholic Fatty Liver Disease Reflects the Metabolic Syndrome and Visceral Fat Accumulation
- M. Hamaguchi, T. Kojima, +10 authors T. Okanoue
- The American Journal of Gastroenterology
- 1 December 2007
The scoring system with abdominal ultrasonography could provide accurate information about hepatic steatosis, visceral obesity, and the metabolic syndrome in apparently healthy people who do not consume alcohol. Expand
The utility of PPARs ligands in models for autoimmune disease is shown, and it is examined that these ligands have the possibility of application for useful treatments of human autoimmune diseases. Expand
ABCB1 C3435T polymorphism influences methotrexate sensitivity in rheumatoid arthritis patients.
- R. Takatori, K. Takahashi, +10 authors T. Kubo
- Clinical and experimental rheumatology
- 1 September 2006
It is suggested that the genetic diagnosis of ABCB1 C3435T can be applied to determine MTX sensitivity for the treatment of RA patients, however, further pharmacokinetics studies are required in this regard. Expand
Telmisartan is a potent target for prevention and treatment in human prostate cancer.
Telmisartan is a potent target for prevention and treatment in PC because it may mediate potent antiproliferative effects against PC cells through PPAR-gamma. Expand
Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases.
Rat models appear to provide a powerful complementary approach to identify and characterize candidate genes that may contribute to autoimmune diseases in several species, and an analysis of conserved synteny among rats, mice, and humans suggested that Aia2 and Aia3/Cia3, like Aia1/CIA1, contain candidate genes for several autoimmune/inflammatory diseases in mice and humans. Expand
Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression.
It is suggested that S 1P signaling via S1P receptors plays an important role in cell proliferation and inflammatory cytokine-induced COX-2 expression and PGE2 production by RA synoviocytes and regulation of S1p/S1P1 signaling may represent a novel therapeutic target in RA. Expand
Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2.
- Y. Tsubouchi, Y. Kawahito, M. Kohno, K. Inoue, T. Hla, H. Sano
- Chemistry, Medicine
- Biochemical and biophysical research…
- 18 May 2001
15d-PGJ2, but not TRO and other prostanoids, suppressed interleukin (IL)-1beta-induced PGE2 synthesis in rheumatoid synovial fibroblasts (RSFs) through the inhibition of cyclooxygenase (COX-2) and cytosolic phospholipase A2 (cPLA2) expression, providing new insight into the feedback mechanism of the arachidonate cascade. Expand
15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats.
It is demonstrated that synovial tissue localized expression of PPAR-gamma in patients with rheumatoid arthritis (RA) and its ligands, especially 15d-PGJ(2), may be useful in the treatment of RA, suggesting that PPAR -gamma may be an important immunoinflammatory mediator. Expand