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Redirection of Silencing Targets by Adenosine-to-Inosine Editing of miRNAs
- Y. Kawahara, Boris Zinshteyn, P. Sethupathy, H. Iizasa, A. Hatzigeorgiou, K. Nishikura
- 23 February 2007
Repression of phosphoribosyl pyrophosphate synthetase 1, a target of the edited miR-376 RNA and an enzyme involved in the uric-acid synthesis pathway, contributes to tight and tissue-specific regulation of uri-acid levels, revealing a previously unknown role for RNA editing in miRNA-mediated gene silencing.
RNA editing of the microRNA‐151 precursor blocks cleavage by the Dicer–TRBP complex
- Y. Kawahara, Boris Zinshteyn, T. Chendrimada, R. Shiekhattar, K. Nishikura
- BiologyEMBO reports
- 1 August 2007
Evidence is provided that RNA editing of pri‐miR‐151 results in complete blockage of its cleavage by Dicer and accumulation of edited pre‐miRNAs, showing a new regulatory role of A → I RNA editing in miRNA biogenesis.
TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes
A previously uncharacterized role for TDP-43 is supported in posttranscriptional regulation of miRNA expression in both the nucleus and the cytoplasm and is shown to be indispensable for neuronal outgrowth.
Frequency and fate of microRNA editing in human brain
It is predicted that ∼16% of human pri-miRNAs are subject to A→I editing and, thus, miRNA editing could have a large impact on the miRNA-mediated gene silencing and four new edited miRNAs with altered seed sequences were identified by targeted cloning and sequencing of the mi RNAs that would be processed from edited pri-MiRNAs.
Glutamate receptors: RNA editing and death of motor neurons
A defect in the editing of the messenger RNA encoding the GluR2 subunit of glutamate AMPA receptors in the spinal motor neurons of individuals affected by ALS will interfere with the correct functioning of the glutamate receptors and may be a contributory cause of neuronal death in ALS patients.
Circulating p53-Responsive MicroRNAs Are Predictive Indicators of Heart Failure After Acute Myocardial Infarction
In the sera of post-AMI patients who experienced development of de-novo HF within 1 year of AMI onset, the levels of 3 p53-responsive microRNAs had been elevated by the early convalescent stage of AMB, suggesting they function as circulating regulators of HF development via the p53 pathway.
Direct binding of Ataxin-2 to distinct elements in 3' UTRs promotes mRNA stability and protein expression.
A-to-I RNA Editing and Human Disease
The recent knowledge on where disturbances in A-to-I RNAediting have been correlated with human disease phenotypes is reviewed.
Tissue- and Plasma-Specific MicroRNA Signatures for Atherosclerotic Abdominal Aortic Aneurysm
- K. Kin, S. Miyagawa, Y. Sawa
- Biology, MedicineJournal of the American Heart Association
- 1 October 2012
The expression of some microRNAs was specifically upregulated in AAA tissue, warranting further studies on the microRNA function in AAA pathogenesis and on the possibility of using a microRNA biomarker for AAA diagnosis.
Human spinal motoneurons express low relative abundance of GluR2 mRNA: an implication for excitotoxicity in ALS
The first quantitative measurements of the expression profile of AMPA receptor subunits mRNAs in human single neurons are provided by means of quantitative RT–PCR with a laser microdissector, showing that among the AMPA subunits, GluR2 shared the vast majority throughout the neuronal subsets and tissues examined.