Y. Kawaguchi

Publications70
h-index12
Citations478
Highly Influential Citations19
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Mechanism of the Conversion of Xanthine Dehydrogenase to Xanthine Oxidase
TLDR
Evidence is presented that the Cys535 and Cys992 residues of rat liver enzyme are indeed involved in the rapid conversion from the dehydrogenase to the oxidase, and that these residues are responsible for the slow conversion.
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The C‐terminal peptide plays a role in the formation of an intermediate form during the transition between xanthine dehydrogenase and xanthine oxidase
TLDR
Results indicate that the dehydrogenase–oxidase transformation occurs rather readily and the insertion of the C‐terminal peptide into the active site cavity of its subunit stabilizes the dehydration form, and it is proposed that the intermediate form can be generated (e.g. in endothelial cells) upon interaction of the EMT portion of the enzyme with other proteins or the cell membrane.
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DNA Damage and Survival Time Course of Deinococcal Cell Pellets During 3 Years of Exposure to Outer Space
TLDR
The results indicated the importance of the aggregated form of cells for surviving in harsh space environment and support the possibility of microbial cell aggregates (pellets) as an ark for interplanetary transfer of microbes within several years.
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Crystal structures of urate bound form of xanthine oxidoreductase: substrate orientation and structure of the key reaction intermediate.
TLDR
The crystal structures of the urate complexes of the demolybdo-form of the D428A mutant of rat xanthine oxidoreductase of the reduced bovine milk enzyme indicate the catalytically relevant binding mode of the substrate Xanthine.
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Investigation of the Interplanetary Transfer of Microbes in the Tanpopo Mission at the Exposed Facility of the International Space Station.
TLDR
The goal of this review is to introduce an overview of the Tanpopo mission with particular emphasis on the investigation of the interplanetary transfer of microbes.
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The Possible Interplanetary Transfer of Microbes: Assessing the Viability of Deinococcus spp. Under the ISS Environmental Conditions for Performing Exposure Experiments of Microbes in the Tanpopo…
TLDR
It is concluded that aggregated deinococcal cells will survive the yearlong exposure experiments of the International Space Station, and it is proposed that microbial cells can aggregate as an ark for the interplanetary transfer of microbes, and is named ‘massapanspermia’.
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Proteometabolomic response of Deinococcus radiodurans exposed to UVC and vacuum conditions: Initial studies prior to the Tanpopo space mission
TLDR
The effectiveness of the integrative proteometabolomic approach as a tool in molecular analysis of microbial stress response caused by space-related factors is revealed.
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Proteomic and Metabolomic Profiling of Deinococcus radiodurans Recovering After Exposure to Simulated Low Earth Orbit Vacuum Conditions
TLDR
Combined comparative analysis of alterations in the proteome and metabolome helps to identify molecular key players in the stress response of D. radiodurans, thus elucidating the mechanisms behind its extraordinary regenerative abilities and enabling this microorganism to withstand vacuum stress.
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Design of a silica-aerogel-based cosmic dust collector for the Tanpopo mission aboard the International Space Station
We are developing a silica-aerogel-based cosmic dust collector for use in the Tanpopo experiment to be conducted on the International Space Station. The mass production of simple two-layer…
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Understanding the molecular mechanism underlying the high catalytic activity of p-hydroxybenzoate hydroxylase mutants for producing gallic acid.
TLDR
This study reported how the L199V/Y385F double mutant exhibits 4.3-fold higher activity for producing gallic acid than the Y385F single mutant, which is primarily due to the suppression of a shunt reaction that wastes reduced nicotinamide adenine dinucleotide phosphate by producing H2O2.
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