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The CREB Coactivator TORC2 Functions as a Calcium- and cAMP-Sensitive Coincidence Detector
TLDR
A signaling module that mediates the synergistic effects of these pathways on cellular gene expression by stimulating the dephosphorylation and nuclear entry of TORC2, a CREB coactivator, consists of the calcium-regulated phosphatase calcineurin and the Ser/Thr kinase SIK2, both of which associate withTORC2.
Adipose-specific Expression, Phosphorylation of Ser794 in Insulin Receptor Substrate-1, and Activation in Diabetic Animals of Salt-inducible Kinase-2*
TLDR
The results suggest that highly expressed SIK2 in insulin-stimulated adipocytes phosphorylates Ser794 of IRS-1 and, as a result, might modulate the efficiency of insulin signal transduction, eventually causing the insulin resistance in diabetic animals.
Silencing the constitutive active transcription factor CREB by the LKB1‐SIK signaling cascade
TLDR
The results suggest that LKB1 and its downstream SIK play an important role in silencing CREB activity via the phosphorylation of TORC, and such silencing may be indispensable for the regulated activation of CREB.
Salt-inducible kinase (SIK) isoforms: their involvement in steroidogenesis and adipogenesis
TLDR
Results strongly suggest that SIK2 may play important role(s) in modulating the insulin-signaling cascade of adipocytes, and thus, may be involved in the development of insulin resistance.
Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm.
TLDR
The results indicate that the RK-rich region of SIK1 is important for determining the nuclear localization and attenuating CREB-repressing activity, but the degree of thenuclear localization of Sik1 itself does not necessarily reflect the degreeof SIK 1-mediated CREB repression.
Characterization of the adrenal-specific antigen IZA (inner zone antigen) and its role in the steroidogenesis
TLDR
The available evidence suggests that IZA may have an important role in the functions of the adrenal zona fasciculata and reticularis and the involvement of IZA in progesterone metabolism is suggested.
ACTH-induced Nucleocytoplasmic Translocation of Salt-inducible Kinase
TLDR
It is shown that SIK changes its subcellular location after the addition of ACTH, and this intracellular translocation of SIK, a CRE-repressor, may account for the time-dependent change in the level ofACTH-activated expression of the StAR protein gene.
Salt-inducible kinase in steroidogenesis and adipogenesis
TLDR
Members of the SIK family are emerging as important modulators of key processes such as steroid hormone biosynthesis by the adrenal cortex and insulin signaling in adipocytes, suggesting that SIK2 might be involved in metabolic regulation in adipose tissue.
Salt-inducible kinase is involved in the ACTH/cAMP-dependent protein kinase signaling in Y1 mouse adrenocortical tumor cells.
TLDR
Results suggested that salt-inducible kinase might play an important role(s) in the cAMP-dependent, but Ad4BP/steroidogenic factor-1-independent, gene expression of cholesterol side-chain cleavage cytochrome P450 in adrenocortical cells.
Histamine production by cultured microglial cells of the mouse
TLDR
Findings indicate that microglia is a third cell type producing histamine in the brain, and was induced by LPS treatment and was sensitive to calmodulin-dependent kinase II inhibitor, KN62.
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