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Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors.
TLDR
It is indicated that PCBs can interfere with TH signaling in the fetal brain by direct actions on the fetus rather than by producing maternal hypothyroidism.
Hg, Zn and Cu levels in the muscle and liver of tiger sharks (Galeocerdo cuvier) from the coast of Ishigaki Island, Japan: relationship between metal concentrations and body length.
TLDR
The Muscle Hg levels were higher than liver concentrations in immature sharks, with the inverse trend observed in mature sharks, and the Zn and Cu concentrations in the liver tended to decrease with increasing body length.
Levels and regional trends of persistent organochlorines and polybrominated diphenyl ethers in Asian breast milk demonstrate POPs signatures unique to individual countries.
TLDR
The present study indicates that the DDTs in breast milk from China and Vietnam had gradually decreased during the last decade, but were still 5-10 times higher than those in other nations.
Simultaneous determination by APCI-LC/MS/MS of hydroxylated and methoxylated polybrominated diphenyl ethers found in marine biota.
TLDR
The APCI-LC/MS/MS method provides the different LOQ ranges between hydroxylated and neutral brominated analogs, and future work could apply the method to the full range of PBDE-like contaminants present in the environment and in biota tissues.
Hydroxylation and methylthiolation of mono-ortho-substituted polychlorinated biphenyls in rats: identification of metabolites with tissue affinity.
TLDR
Another metabolism of mono-ortho-PCBs PCBs involved methylthiolation in the vicinal ortho and meta unsubstituted positions to give methylthio metabolites, which were detected as methylsulfonyl metabolites in liver and adipose tissue.
Halogenated bipyrroles and methoxylated tetrabromodiphenyl ethers in tiger shark (Galeocerdo cuvier) from the southern coast of Japan.
TLDR
The present study suggests that the concentrations of natural HBPs in the liver are size (age)-dependent whereas MeO-tetraBDEs have species-specific biomagnification potentials.
Effects of polychlorinated biphenyls, kanechlor-500, on serum thyroid hormone levels in rats and mice.
TLDR
It is found for the first time that the decrease in serum T4 levels by KC-500 in mice occurred without increase in hepatic UDP-GTs, UGT1A1 and UGT 1A6, responsible for T4 glucuronidation.
Hepatic UDP-Glucuronosyltransferases Responsible for Glucuronidation of Thyroxine in Humans
TLDR
Findings indicated strongly that glucuronidation of T4 in the human liver was mediated by UGT1A subfamily enzymes, especially UGT 1Al and U GT1A3, and further suggested that the interindividual differences would come from differences in the expression levels of Ugt1A1 and UGT2B in individual human livers.
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