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The mechanism of aggravation of indomethacin-induced gastric ulcers by adrenalectomy in the rat.
TLDR
The results indicate that the adrenal cortex, particularly the area containing glucocorticoids, plays an important role in suppression of the noxious effect of indomethacin on the rat gastric mucosa. Expand
Pharmacological and electrophysiological discrimination of contractile responses to selective alpha 1- and alpha 2-adrenoceptor agonists in rat tail artery.
TLDR
The results suggest the heterogeneity of postsynaptic alpha-adrenoceptors in the rat tail artery and may indicate the differences in the Ca2+ movement for the contractions produced by alpha 1- and alpha 2- adrenoceptor agonists. Expand
Attenuation of the development of hypertension in spontaneously hypertensive rats by chronic oral administration of eicosapentaenoic acid.
TLDR
Daily oral administration of 30 to 300 mg/kg EPA for eight weeks significantly decreased the development of hypertension in SHR dose-dependently and may be useful as a hypotensive agent for treatment of hypertension. Expand
Selective abolition of Ca-dependent responses of smooth and cardiac muscles by flunarizine.
TLDR
The experiments indicate that flunarizine is selective in antagonizing Ca-dependent contraction of the rabbit basilar artery, probably by blockade of the transmembrane Ca. Expand
Vasodilating effect of flunarizine in anesthetized dogs.
TLDR
There was no significant difference between the changes in vertebral, hindquarter and mesenteric vascular resistances induced by flunarIZine and cinnarizine, while the duration of the vasodilating effect of flunaraizine was longer than that of cinnARizine especially in the vertebral vascular bed. Expand
Effects of aminoglycoside antibiotics on cholinergic autonomic nervous transmission.
TLDR
The results suggest that the site for the block of aminoglycosides is mainly the cholinergic nerve terminal, where they reduce the available Ca ions required for the release of ACh. Expand
Effects of nipradilol (K-351) on alpha-adrenoceptor mediated responses in various isolated tissues.
TLDR
The results suggest that nipradilol possesses an alpha 1-adrenoceptor blocking action; it possesses very weak or practically no presynaptic alpha 2-blocking activity but shows a non-competitive antagonistic action on postsynapticalpha 2-adRenoceptor mediated contractile responses. Expand
Cardiovascular effects of cimetidine.
Influence of surgical sympathectomy on gastric secretion and ulceration in rats.
TLDR
The sympathectomy worsened the stress- and the indomethacin- induced ulcer and delayed the healing of chronic gastric ulcers a little but not significantly, and had no deteriorative influence on the reserpine-induced ulcers. Expand
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