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Latrunculins--novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D.
This comparison showed that the transient effects of latrunculin B were fully reversible for the NIL8 cells and not for the mouse neuroblastoma N1E-115 cells, suggesting differences in the in vivo mode of action of the two classes of drugs.
Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells.
Two toxins, latrunculins A and B, which contain a new class of 16- and 14-membered marine macrolides attached to the rare 2-thiazolidinone moiety, were purified recently from the Red Sea sponge Latrunculia magnifica and reveal that the toxins cause major alterations in the organization of microfilaments without obvious effects on the organizations of the microtubular system.
The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum.
Calanolide A was active not only against the AZT-resistant G-9106 strain of HIV-1 but also against the pyridinone-resistant A17 strain, which was of particular interest since the A17 virus is highly resistant to previously known HIV- 1 specific, non-nucleoside RT inhibitors.
Suppressors of cancer cell proliferation from fig (Ficus carica) resin: isolation and structure elucidation.
Both the natural and the synthetic compounds showed in vitro inhibitory effects on proliferation of various cancer cell lines and identity was established by spectroscopic methods (NMR, MS) and confirmed by chemical synthesis.
Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain
It is shown that incensole acetate (IA), a Boswellia resin constituent, is a potent TRPV3 agonist that causes anxiolytic‐like and antide‐pressive‐like behavioral effects in wild‐type mice with concomitant changes in c‐Fos activation in the brain.
Antimicrobial activity of the reef sponge Amphimedon viridis from the Red Sea: evidence for selective toxicity
Testing the activity of crude organic extracts of 11 dominant Red Sea reef sponges against a panel of bacteria isolated from their natural environment found Amphimedon viridis (Keller) exhibited the highest antimicrobial activity.
Antimicrobial activity of a Red Sea soft coral, Parerythropodium fulvum fulvum: reproductive and developmental considerations
It is concluded that antimicrobial activity detected in the extracts of P. f.