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Antiallodynic Effect of Herbal Medicine Yokukansan on Peripheral Neuropathy in Rats with Chronic Constriction Injury
TLDR
The results suggest that yokukansan was confirmed to have antiallodynic effects in CCI rats, which are related to a blockade of glutamatergic neurotransmission via activation of glutamate transporters in the spinal cord. Expand
Potentiation of ghrelin signaling attenuates cancer anorexia–cachexia and prolongs survival
TLDR
It is demonstrated that the integrated mechanism underlying cancer anorexia–cachexia involves lowered ghrelin signaling due to excessive hypothalamic interactions of 5-HT with CRF through the 5- HT2cR. Expand
The Blood–Brain Barrier Permeability of Geissoschizine Methyl Ether in Uncaria Hook, a Galenical Constituent of the Traditional Japanese Medicine Yokukansan
TLDR
In vitro and in vivo BBB permeability data suggest that target ingredient GM in yokukansan administered orally is absorbed into the blood and then reaches the brain through the BBB, which further supports the possibility that GM is an active component in the psychotropic effect of yokUKansan. Expand
Mechanisms for Contractile Effect of Dai-kenchu-to in Isolated Guinea Pig Ileum
TLDR
The results suggest that contractile response induced by TJ-100 is partially mediated by ACh released from the cholinergic nerve endings and that 5-HT4 receptors would be involved in the effect of TJ- 100. Expand
Effects of Dai-kenchu-to on intestinal obstruction following laparotomy.
TLDR
Dai-kenchu-to demonstrates positive effect on postoperative ileus, and is suggested to prevent postoperative intestinal adhesion by gastroprokinetic and anti inflammatic effects. Expand
Effect of the rhizomes of Atractylodes lancea and its constituents on the delay of gastric emptying.
TLDR
It is suggested that the aqueous extract improved the delayed gastric emptying, and polyacetylenic compounds contributed to its activity. Expand
Mechanisms by which Hange-shashin-to reduces prostaglandin E2 levels.
TLDR
The results suggest that the effect of TJ-14 in decreasing PGE2 is partially mediated by corticosterone and inhibition of COX-2, and the constituents Scutellariae Radix, Glycyrrhizae Radix and Coptidis Rhizoma were believed to be involved in COX. Expand
Effects of rikkunshi-to, a traditional Japanese medicine, on the delay of gastric emptying induced by N(G)-nitro-L-arginine.
TLDR
It is suggested that Rikkunshi-to ameliorated abnormalities of NO-mediated gastric functions such as delayed gastric emptying, and hesperidin and L-arginine were identified as two of the active ingredients contributing to the ability of Rikkunashi-to to facilitate gastrics emptying. Expand
Neuroprotective effects of yokukansan, a traditional japanese medicine, on glutamate-mediated excitotoxicity in cultured cells
TLDR
The results suggest that TJ-54 may exert a neuroprotective effect against glutamate-induced excitotoxicity not only by amelioration of dysfunction of astrocytes but also by direct protection of neuronal cells. Expand
Isoliquiritigenin is a Novel NMDA Receptor Antagonist in Kampo Medicine Yokukansan
TLDR
The present results suggest that neuroprotective components (isoliquiritigenin, glycycoumarin, liquiritin, and 18β-glycyrrhetinic acid) are contained in yokukansan, and isoliquiritigin, which is one of them, is a novel NMDA receptor antagonist. Expand
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