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Establishment of sister chromatid cohesion at the S. cerevisiae replication fork.
Two identical sister copies of eukaryotic chromosomes are synthesized during S phase. To facilitate their recognition as pairs for segregation in mitosis, sister chromatids are held together fromExpand
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Rif1 is a global regulator of timing of replication origin firing in fission yeast.
One of the long-standing questions in eukaryotic DNA replication is the mechanisms that determine where and when a particular segment of the genome is replicated. Cdc7/Hsk1 is a conserved kinaseExpand
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Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements.
Chromosome replication initiates at multiple replicons and terminates when forks converge. In E. coli, the Tus-TER complex mediates polar fork converging at the terminator region, and aberrantExpand
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  • Open Access
Rif1 regulates the replication timing domains on the human genome
DNA replication is spatially and temporally regulated during S‐phase. DNA replication timing is established in early‐G1‐phase at a point referred to as timing decision point. However, how theExpand
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  • Open Access
Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo.
The phosphoinositide (PI)-3-kinase-related kinase (PIKK) family proteins Tel1p and Mec1p have been implicated in the telomere integrity of Saccharomyces cerevisiae. However, the mechanism ofExpand
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Multiple pathways can bypass the essential role of fission yeast Hsk1 kinase in DNA replication initiation
A number of different genetic backgrounds and growth conditions bypass DNA replication defects caused by the absence of yeast Hsk1 kinase, demonstrating the plasticity of the eukaryotic DNAExpand
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  • Open Access
Mrc1 Marks Early-Firing Origins and Coordinates Timing and Efficiency of Initiation in Fission Yeast †
ABSTRACT How early- and late-firing origins are selected on eukaryotic chromosomes is largely unknown. Here, we show that Mrc1, a conserved factor required for stabilization of stalled replicationExpand
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Temporal and spatial regulation of eukaryotic DNA replication: from regulated initiation to genome-scale timing program.
Replication origins are where pre-replication complexes are assembled during G1 phase. However, only a subset of the origins is actually "fired" to initiate DNA synthesis during S phase. WhereasExpand
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Genomic organization of the human phosphodiesterase PDE11A gene
PDE11A is a dual-substrate, cAMP and cGMP, cyclic nucleotide phosphodiesterase (PDE). Presently four unique variants carrying distinct GAF sequences in the N-terminal region have been identified.Expand
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Regulation of DNA Replication Timing on Human Chromosome by a Cell-Type Specific DNA Binding Protein SATB1
Background Replication timing of metazoan DNA during S-phase may be determined by many factors including chromosome structures, nuclear positioning, patterns of histone modifications, andExpand
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