• Publications
  • Influence
Phosphatidylinositol 4-Phosphate 5-Kinase α Is a Downstream Effector of the Small G Protein ARF6 in Membrane Ruffle Formation
Synthesis of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], a signaling phospholipid, is primarily carried out by phosphatidylinositol 4-phosphate 5-kinase [PI(4)P5K], which has been reported toExpand
  • 768
  • 42
Local Change in Phospholipid Composition at the Cleavage Furrow Is Essential for Completion of Cytokinesis*
Cell division ends up with the membrane separation of two daughter cells, presumably by a membrane fusion that requires dynamic changes of the distribution and the composition of membrane lipids. WeExpand
  • 166
  • 18
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1
Proper neutrophil migration into inflammatory sites ensures host defense without tissue damage. Phosphoinositide 3-kinase (PI(3)K) and its lipid product phosphatidylinositol 3,4,5-trisphosphateExpand
  • 270
  • 13
Phosphatidylinositol-4-phosphate 5-Kinase Localized on the Plasma Membrane Is Essential for Yeast Cell Morphogenesis*
Phosphatidylinositol 4,5-biphosphate (PtdIns(4,5)P2), an important element in eukaryotic signal transduction, is synthesized either by phosphatidylinositol-4-phosphate 5-kinase (PtdIns(4)P 5K) fromExpand
  • 162
  • 13
Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis
During chemotaxis, activation of the small guanosine triphosphatase Rac is spatially regulated to organize the extension of membrane protrusions in the direction of migration. In neutrophils, RacExpand
  • 235
  • 9
Regulation of Expression of Phospholipase D1 and D2 by PEA-15, a Novel Protein That Interacts with Them*
Phospholipase D (PLD), a signal-transducing membrane-associated enzyme, is implicated in diverse processes including apoptosis, ERK activation, and glucose transport. Prior studies have identifiedExpand
  • 64
  • 7
The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons
MINT‐7892353, MINT‐7892615, MINT‐7892657, MINT‐7892672, MINT‐7892549, MINT‐7892738: Arf6 (uniprotkb:P62331) physically interacts (MI:0915) with JIP3 (uniprotkb:Q9ESN9) by anti tagExpand
  • 31
  • 7
Role of activation of PIP5Kγ661 by AP‐2 complex in synaptic vesicle endocytosis
Synaptic vesicles (SVs) are retrieved by clathrin‐mediated endocytosis at the nerve terminals. Phosphatidylinositol 4,5‐bisphosphate [PI(4,5)P2] drives this event by recruiting the components of theExpand
  • 74
  • 6
Regulation of PIP5K activity by Arf6 and its physiological significance
The phospholipid kinase phosphatidylinositol 4‐phosphate 5‐kinase (PIP5K) catalyzes the phosphorylation of the membrane phospholipid phosphatidylinositol 4‐phosphate to generate the pleiotropicExpand
  • 54
  • 6
Key Roles for the Lipid Signaling Enzyme Phospholipase D1 in the Tumor Microenvironment During Tumor Angiogenesis and Metastasis
Genetic ablation or pharmacological inhibition of a lipid signaling enzyme attenuates tumor growth and metastasis. Targeting the Tumor Microenvironment Phospholipase D (PLD) is an enzyme thatExpand
  • 91
  • 5