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Inhibitory effect of 5,6,7,8-tetrahydroneopterin on adriamycin-induced cardiotoxicity.
The protective effect of the reduced form of neopterin, 5,6,7,8-tetrahydroneopterin (NPH4), against the cardiotoxicity of adriamycin (ADR) was evaluated in mice by assay of serum creatine
Effect of 5,6,7,8-tetrahydroneopterin on the bovine endothelial cell injury induced by cumene hydroperoxide.
Analysis by electron spin resonance spectrometry indicated that 5,6,7,8-tetrahydroneopterin (NPH4), a reduced form of neopterin, possesses an antioxidant activity in various systems and suggests that NPH4 would be effective against various diseases whose pathogenesis is active oxygen-related.
Studies on topical antiinflammatory corticosteroids. III. Synthesis and vasoconstrictive activity of 11 beta,17 alpha,21-trihydroxy-2'-phenyl-2'H-2,4-pregnadieno[3,2-c]pyrazol- 20-one derivatives.
17α-Acyloxy-11β, 21-dihydroxy-2'-phenyl-2'H-2, 4-pregandieno[3, 2-c]pyrazol-20-one derivatives (3a, 3b, 4, 5a and 5c) were synthesized and tested for vasoconstrictive activities. Compound 3b showed
Studies on Topical Antiinflammatory Corticosteroids. II. : Synthesis and Vasoconstrictive Activity of 11β, 17α, 21-Trihydroxy-6α-methyl-1, 4-pregnadiene-3, 20-dione 17-Methoxy- and
17-Methoxyacetate (3a) and 17-(methylthio)acetate (3b) of 11β, 17α, 21-trihydroxy-6α-methyl-1, 4-pregnadiene-3, 20-dione (6α-methylprednisolone, 1) and their 21-esters (4a and 4b) were synthesized
Inhibition of carbon tetrachloride-induced hepatotoxicity by neopterins.
It is suggested that NP and NPH4 inhibit CCl4-induced hepatotoxicity through different mechanisms.
Pharmacological properties of the new non-sulfhydryl angiotensin converting enzyme inhibitor N-[8-amino-1(S)-carboxyoctyl]-L-alanyl-L-proline.
AB-47 is a highly potent, long-lasting and relatively A-I-selective ACE inhibitor that exhibited higher selectivity for ACE inhibition than for BK inactivation and higherSelectivity than enalaprilat and captopril.
Suppression of ischemia-reperfusion injury in murine models by neopterins.
The results suggest that neopterin may be effective as a protective agent against ischemia-reperfusion injury, in which active oxygen species are believed to play a major role.