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Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.
Oxidative stress is produced under diabetic conditions and possibly causes various forms of tissue damage in patients with diabetes. The aim of this study was to examine the involvement of oxidative… Expand
Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer.
- Y. Umayahara, R. Kawamori, +6 authors T. Kamada
- Biology, Medicine
- The Journal of biological chemistry
- 10 June 1994
As a step toward elucidating the physiological role of insulin-like growth factor-I (IGF-I) in mediating estrogen action, we sought to determine the molecular basis of the phenomenon. In HepG2 cells… Expand
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
The JNK pathway is known to be activated in several tissues in the diabetic state, and is possibly involved in the development of insulin resistance and suppression of insulin biosynthesis. Here we… Expand
Modulation of the JNK Pathway in Liver Affects Insulin Resistance Status*
- Y. Nakatani, H. Kaneto, +7 authors M. Hori
- Medicine, Biology
- Journal of Biological Chemistry
- 29 October 2004
The c-Jun N-terminal kinase (JNK) pathway is known to be activated under diabetic conditions and to possibly be involved in the progression of insulin resistance. In this study, we examined the… Expand
Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation.
The transcription factor pancreatic and duodenal homeobox factor 1 (PDX-1) is expressed in pancreatic progenitor cells. In exocrine pancreas, PDX-1 is down-regulated during late development, while… Expand
The Human Glucokinase Gene β-Cell-Type Promoter: An Essential Role of Insulin Promoter Factor 1/PDX-1 in Its Activation in HIT-T15 Cells
The glycolytic enzyme glucokinase plays a primary role in the glucose-responsive secretion of insulin, and defects of this enzyme can cause NIDDM. As a step toward understanding the molecular basis… Expand
Role of Oxidative Stress in Pancreatic β‐Cell Dysfunction
Abstract: Oxidative stress is produced under diabetic conditions and is likely involved in progression of pancreatic β‐cell dysfunction found in diabetes. Possibly caused by low levels of antioxidant… Expand
Role of oxidative stress in pancreatic beta-cell dysfunction.
Oxidative stress is produced under diabetic conditions and is likely involved in progression of pancreatic beta-cell dysfunction found in diabetes. Possibly caused by low levels of antioxidant enzyme… Expand
Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells.
- T. Matsuoka, Y. Kajimoto, +7 authors Y. Yamasaki
- Biology, Medicine
- The Journal of clinical investigation
Prolonged poor glycemic control in non-insulin-dependent diabetes mellitus patients often leads to a decline in insulin secretion from pancreatic beta cells, accompanied by a decrease in the insulin… Expand
Expression of insulin-like growth factor-I during chicken development.
We have investigated the expression of insulin-like growth factor-I (IGF-I) during ontogeny in the chick. IGF-I mRNA was first detectable in whole embryos on day 6, while serum IGF-I could be… Expand