• Publications
  • Influence
Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality.
Many women with ovarian endometrioid carcinoma present with concurrent endometrial carcinoma. Organ-confined and low-grade synchronous endometrial and ovarian tumors (SEOs) clinically behave asExpand
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Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer
Significance Chromosome instability (CIN) is well established as an enabling characteristic of cancer that contributes to cancer initiation and progression. Here, we identify 245 genes whoseExpand
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Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden
Abstract Endometriosis is a significant risk factor for clear cell and endometrioid ovarian cancers and is often found contiguous with these cancers. Using whole‐genome shotgun sequencing of sevenExpand
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Clear cell carcinomas of the ovary and kidney: clarity through genomics
Clear cell ovarian carcinoma (CCOC) and clear cell renal cell carcinoma (ccRCC) both feature clear cytoplasm, owing to the accumulation of cytoplasmic glycogen. Genomic studies have demonstratedExpand
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Combination of short CAG and GGN repeats in the androgen receptor gene is associated with acne risk in North East China
  • Y. Pang, C. He, +9 authors H. Chen
  • Medicine
  • Journal of the European Academy of Dermatology…
  • 1 December 2008
Background  Acne vulgaris is one of the most common skin disorders, and androgen is known to play a key role in the development of acne. However, the exact genetic mechanism by which androgenExpand
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Integration of Steady-State and Temporal Gene Expression Data for the Inference of Gene Regulatory Networks
We develop a new regression algorithm, cMIKANA, for inference of gene regulatory networks from combinations of steady-state and time-series gene expression data. Using simulated gene expressionExpand
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NAIL, a software toolset for inferring, analyzing and visualizing regulatory networks
Summary: The wide variety of published approaches for the problem of regulatory network inference makes using multiple inference algorithms complex and time-consuming. Network Analysis and InferenceExpand
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Integrated single-nucleotide and structural variation signatures of DNA-repair deficient human cancers
Mutation signatures in cancer genomes reflect endogenous and exogenous mutational processes, offering insights into tumour etiology, features for prognostic and biologic stratification andExpand
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Integrated structural variation and point mutation signatures in cancer genomes using correlated topic models
Mutation signatures in cancer genomes reflect endogenous and exogenous mutational processes, offering insights into tumour etiology, features for prognostic and biologic stratification andExpand
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LINE-1 retrotransposon-mediated DNA transductions in endometriosis associated ovarian cancers.
OBJECTIVE Endometrioid (ENOC) and clear cell ovarian carcinoma (CCOC) share a common precursor lesion, endometriosis, hence the designation endometriosis associated ovarian cancers (EAOC). LongExpand
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