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- Publications
- Influence
ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia.
- Stephen G. Landt, G. Marinov, +44 authors M. Snyder
- Biology, Medicine
- Genome research
- 1 September 2012
Chromatin immunoprecipitation (ChIP) followed by high-throughput DNA sequencing (ChIP-seq) has become a valuable and widely used approach for mapping the genomic location of transcription-factor… Expand
Comprehensive analysis of the chromatin landscape in Drosophila
- P. Kharchenko, A. A. Alekseyenko, +27 authors P. Park
- Biology, Medicine
- Nature
- 1 December 2010
Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we… Expand
Nature and function of insulator protein binding sites in the Drosophila genome.
- Y. Schwartz, D. Linder-Basso, +17 authors V. Pirrotta
- Biology, Medicine
- Genome research
- 1 November 2012
Chromatin insulator elements and associated proteins have been proposed to partition eukaryotic genomes into sets of independently regulated domains. Here we test this hypothesis by quantitative… Expand
The histone chaperone CAF-1 safeguards somatic cell identity
- Sihem Cheloufi, U. Elling, +33 authors K. Hochedlinger
- Biology, Medicine
- Nature
- 10 December 2015
Cellular differentiation involves profound remodelling of chromatic landscapes, yet the mechanisms by which somatic cell identity is subsequently maintained remain incompletely understood. To further… Expand
Enrichment of HP1a on Drosophila Chromosome 4 Genes Creates an Alternate Chromatin Structure Critical for Regulation in this Heterochromatic Domain
- N. C. Riddle, Y. Jung, +13 authors S. Elgin
- Biology, Medicine
- PLoS genetics
- 1 September 2012
Chromatin environments differ greatly within a eukaryotic genome, depending on expression state, chromosomal location, and nuclear position. In genomic regions characterized by high repeat content… Expand
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
- Isidro Cortés-Ciriano, June-Koo Lee, +8 authors P. Park
- Biology
- 30 May 2018
Chromothripsis is a newly discovered mutational phenomenon involving massive, clustered genomic rearrangements that occurs in cancer and other diseases. Recent studies in cancer suggest that… Expand
Sex comb on midleg (Scm) is a functional link between PcG-repressive complexes in Drosophila.
- Hyuckjoon Kang, Kyle A. McElroy, +4 authors M. Kuroda
- Biology, Medicine
- Genes & development
- 1 June 2015
The Polycomb group (PcG) proteins are key regulators of development in Drosophila and are strongly implicated in human health and disease. How PcG complexes form repressive chromatin domains remains… Expand
Genome-Wide Analysis of Wilms' Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms.
- Martin Kann, Sandrine Ettou, +6 authors J. Kreidberg
- Biology, Medicine
- Journal of the American Society of Nephrology…
- 30 January 2015
The transcription factor Wilms' tumor suppressor 1 (WT1) is key to podocyte development and viability; however, WT1 transcriptional networks in podocytes remain elusive. We provide a comprehensive… Expand
Sequence-Specific Targeting of Dosage Compensation in Drosophila Favors an Active Chromatin Context
- A. A. Alekseyenko, J. Ho, +16 authors P. Park
- Biology, Medicine
- PLoS genetics
- 1 April 2012
The Drosophila MSL complex mediates dosage compensation by increasing transcription of the single X chromosome in males approximately two-fold. This is accomplished through recognition of the X… Expand