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Carbachol stimulation of phospholipase A2 and insulin secretion in pancreatic islets.
It is shown, for the first time, that the muscarinic agonist carbachol, at concentrations which stimulate insulin secretion, causes a rapid and nearly 3-fold increase in arachidonic acid accumulation in islets. Expand
Inhibition of phospholipase A2 and insulin secretion in pancreatic islets.
The observations suggest that glucose-induced arachidonate increase is essential for insulin secretion, which is specific for phospholipase A2. Expand
Muscarinic Regulation of Alzheimer's Disease Amyloid Precursor Protein Secretion and Amyloid β-Protein Production in Human Neuronal NT2N Cells (*)
The results suggest that APP-S secretion and Aβ production in NT2N neurons are regulated by the muscarinic/phospholipase C signal transduction pathway. Expand
Transient activation of calcium-dependent phospholipase A2 by insulin secretagogues in isolated pancreatic islets.
It is suggested that activation of islet Ca(2+)-dependent phospholipase A2 may be important in a distal process of insulin secretion, such as secretory granule exocytosis. Expand
U-73122 does not specifically inhibit phospholipase C in rat pancreatic islets and insulin-secreting beta-cell lines.
Observations suggest that U-73122 does not specifically inhibit phospholipase C in insulin-secreting cells. Expand
Fuel secretagogue stimulation of arachidonic acid accumulation in fresh and cultured pancreatic islets
It is shown that non-metabolizable analogs of glucose which do not stimulate insulin secretion fail to cause significant accumulation of unesterified arachidonic acid in pancreatic islets. Expand
Glucose and carbachol synergistically stimulate phosphatidic acid accumulation in pancreatic islets.
The data suggest that phosphatidic acid may have a central role in insulin secretion as an intracellular mediator, and possible mechanisms include de novo synthesis from glucose and/or activation of phospholipase D. Expand
Oil-in-water solar comprising a lipophilic ethylenic polymer, silica and a mixture of nonionic surfactants.
Oil-in-water emulsion comprises, in a medium, (a) a continuous aqueous phase, (b) a discontinuous oil phase, (c) a photoprotective system, (d) at least one lipophilic ethylene polymer comprising (i)Expand
Cosmetic or dermatological composition comprising a merocyanine and an oily phase comprising at least one ester of di or tricarboxylic acid
La presente invention concerne une composition notamment cosmetique ou dermatologique comprenant dans un support physiologiquement acceptable : a) au moins une merocyanine de formule (1) ou (2) b) auExpand