• Publications
  • Influence
Regulation of a DLK-1 and p38 MAP Kinase Pathway by the Ubiquitin Ligase RPM-1 Is Required for Presynaptic Development
Synapses display a stereotyped ultrastructural organization, commonly containing a single electron-dense presynaptic density surrounded by a cluster of synaptic vesicles. The mechanism controllingExpand
  • 301
  • 42
A Genetically Encoded Tag for Correlated Light and Electron Microscopy of Intact Cells, Tissues, and Organisms
Electron microscopy (EM) achieves the highest spatial resolution in protein localization, but specific protein EM labeling has lacked generally applicable genetically encoded tags for in situExpand
  • 598
  • 34
  • PDF
The DLK-1 Kinase Promotes mRNA Stability and Local Translation in C. elegans Synapses and Axon Regeneration
Growth cone guidance and synaptic plasticity involve dynamic local changes in proteins at axons and dendrites. The Dual-Leucine zipper Kinase MAPKKK (DLK) has been previously implicated inExpand
  • 294
  • 32
  • PDF
The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans
At synaptic junctions, specialized subcellular structures occur in both pre- and postsynaptic cells. Most presynaptic termini contain electron-dense membrane structures, often referred to as activeExpand
  • 345
  • 28
  • PDF
SYD-2 Liprin-α organizes presynaptic active zone formation through ELKS
A central event in synapse development is formation of the presynaptic active zone in response to positional cues. Three active zone proteins, RIM, ELKS (also known as ERC or CAST) and Liprin-α, bindExpand
  • 187
  • 24
  • PDF
The Caenorhabditis elegans Gene unc-25Encodes Glutamic Acid Decarboxylase and Is Required for Synaptic Transmission But Not Synaptic Development
The neurotransmitter GABA has been proposed to play a role during nervous system development. We show that theCaenorhabditis elegans gene unc-25encodes glutamic acid decarboxylase (GAD), the GABAExpand
  • 241
  • 22
  • PDF
Calcium and Cyclic AMP Promote Axonal Regeneration in Caenorhabditis elegans and Require DLK-1 Kinase
Axons of adult Caenorhabditis elegans neurons undergo robust regenerative growth after laser axotomy. Here we show that axotomy of PLM sensory neurons triggers axonal calcium waves whose amplitudeExpand
  • 227
  • 22
  • PDF
Coordinated Transcriptional Regulation of the unc-25Glutamic Acid Decarboxylase and the unc-47 GABA Vesicular Transporter by the Caenorhabditis elegans UNC-30 Homeodomain Protein
An important aspect of the specification of neuronal fate is the choice of neurotransmitter. In Caenorhabditis elegansthe neurotransmitter GABA is synthesized by the UNC-25 glutamic acidExpand
  • 146
  • 18
  • PDF
Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein
THE Caenorhabditis elegans gene unc-30 is required for the develop-ment and functioning of the 19 inhibitory GABAergic (γ-aminobutyric-acid-secreting) type D motor neurons, which controlExpand
  • 222
  • 17
The SAD-1 Kinase Regulates Presynaptic Vesicle Clustering and Axon Termination
During synapse formation, presynaptic axon outgrowth is terminated, presynaptic clusters of vesicles are associated with active zone proteins, and active zones are aligned with postsynapticExpand
  • 173
  • 17
  • PDF