Y. Jigami

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OCH1 encodes a novel membrane bound mannosyltransferase: outer chain elongation of asparagine-linked oligosaccharides.

Keiichi I Nakayama, Takeshi Nagasu, Yoh-ichi Shimma, Junro Kuromitsu, Y. Jigami
The EMBO journal
1992

The Saccharomyces cerevisiae och1 mutant shows a deficiency in the mannose outer chain elongation at the non-permissive temperature. We have cloned the OCH1 gene by complementation of temperature… (More)

PER1 is required for GPI-phospholipase A2 activity and involved in lipid remodeling of GPI-anchored proteins.

Morihisa Fujita, Mariko Umemura, Takehiko Yoko-O, Y. Jigami
Molecular biology of the cell
2006

Glycosylphoshatidylinositol (GPI) anchors are remodeled during their transport to the cell surface. Newly synthesized proteins are transferred to a GPI anchor, consisting of diacylglycerol with… (More)

Demonstration of mammalian protein O-mannosyltransferase activity: coexpression of POMT1 and POMT2 required for enzymatic activity.

Hiroshi Manya, Atsuro Chiba, +5 authors Tamao Endo
Proceedings of the National Academy of Sciences…
2004

Defects in O-mannosylation of alpha-dystroglycan are thought to cause certain types of congenital muscular dystrophies with neuronal migration disorders. Among these muscular dystrophies,… (More)

Fatty acid remodeling of GPI-anchored proteins is required for their raft association.

Yusuke Maeda, Yuko Tashima, +5 authors Taroh Kinoshita
Molecular biology of the cell
2007

Whereas most of the cellular phosphatidylinositol (PI) contain unsaturated fatty chains and are excluded from rafts, GPI-anchored proteins (APs) unusually contain two saturated fatty chains in their… (More)

Functional analysis of Arabidopsis thaliana RHM2/MUM4, a multidomain protein involved in UDP-D-glucose to UDP-L-rhamnose conversion.

Takuji Oka, Tadashi Nemoto, Y. Jigami
The Journal of biological chemistry
2007

UDP-L-rhamnose is required for the biosynthesis of cell wall rhamnogalacturonan-I, rhamnogalacturonan-II, and natural compounds in plants. It has been suggested that the RHM2/MUM4 gene is involved in… (More)

Inositol deacylation by Bst1p is required for the quality control of glycosylphosphatidylinositol-anchored proteins.

Morihisa Fujita, Takehiko Yoko-O, Y. Jigami
Molecular biology of the cell
2006

Misfolded proteins are recognized in the endoplasmic reticulum (ER), transported back to the cytosol, and degraded by the proteasome. A number of proteins are processed and modified by a… (More)

Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter.

Shin Kamiyama, Takeshi Suda, +11 authors Shoko Nishihara
The Journal of biological chemistry
2003

Nucleotide sulfate, namely 3'-phosphoadenosine 5'-phosphosulfate (PAPS), is a universal sulfuryl donor for sulfation. Although a specific PAPS transporter is present in Golgi membrane, no study has… (More)

Mannosylphosphate transfer to yeast mannan.

Y. Jigami, Tomoyuki Odani
Biochimica et biophysica acta
1999

Mannoproteins located in the outermost layer of yeast cell wall determine the wall's porosity and thereby regulate leakage of proteins from the periplasmic space and entrance of macromolecules from… (More)

Structure of the N-linked oligosaccharides that show the complete loss of alpha-1,6-polymannose outer chain from och1, och1 mnn1, and och1 mnn1 alg3 mutants of Saccharomyces cerevisiae.

Y. Nakanishi-Shindo, Kazuhisa Nakayama, Aki Tanaka, Yumiko Toda, Y. Jigami
The Journal of biological chemistry
1993

The periplasmic invertase was purified from Saccharomyces cerevisiae och1::LEU2 disruptant cells (delta och1), which have a defect in elongation of the outer chain attached to the N-linked core… (More)

Comparison of the effects of agalsidase alfa and agalsidase beta on cultured human Fabry fibroblasts and Fabry mice

Hitoshi Sakuraba, Mai Murata-Ohsawa, +9 authors Kohji Itoh
Journal of Human Genetics
2006

AbstractWe compared two recombinant α-galactosidases developed for enzyme replacement therapy for Fabry disease, agalsidase alfa and agalsidase beta, as to specific α-galactosidase activity,… (More)

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