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Juglone-induced apoptosis in human gastric cancer SGC-7901 cells via the mitochondrial pathway.
This study was designed to investigate the effect of juglone on the apoptosis of human gastric cancer SGC-7901 cells. The cytotoxic activity of juglone on SGC-7901 cells was tested by the… Expand
Saponins isolated from Asparagus induce apoptosis in human hepatoma cell line HepG2 through a mitochondrial-mediated pathway.
OBJECTIVE Many scientific studies have shown that Asparagus officinalis has an antitumour effect and enhances human immunity, but the active components and the antitumour mechanisms are unclear. We… Expand
Screening mutations of OTOF gene in Chinese patients with auditory neuropathy, including a familial case of temperature-sensitive auditory neuropathy
BackgroundMutations in OTOF gene, encoding otoferlin, cause DFNB9 deafness and non-syndromic auditory neuropathy (AN). The aim of this study is to identify OTOF mutations in Chinese patients with… Expand
Active components alignment of Gegenqinlian decoction protects ulcerative colitis by attenuating inflammatory and oxidative stress.
ETHNOPHARMACOLOGICAL RELEVANCE Gegenqinlian Decoction (GQD) has been used as a folk remedy for gastrointestinal diseases in China over thousands of years. It has significant treatment efficacy for… Expand
Sulfated modification and anti-tumor activity of laminarin
The aim of this study was to investigate the sulfated modification of laminarin and the changes in structure and antitumor activity. The chlorosulfonic acid-pyridine method was applied for sulfated… Expand
Mitochondria, Cybrids, Aging, and Alzheimer's Disease.
- R. Swerdlow, S. Koppel, I. Weidling, C. Hayley, Y. Ji, H. Wilkins
- Biology, Medicine
- Progress in molecular biology and translational…
Mitochondrial and bioenergetic function change with advancing age and may drive aging phenotypes. Mitochondrial and bioenergetic changes are also documented in various age-related neurodegenerative… Expand
Targeted gene capture and massively parallel sequencing identify TMC1 as the causative gene in a six‐generation Chinese family with autosomal dominant hearing loss
- Xue Gao, Shasha Huang, +8 authors P. Dai
- Biology, Medicine
- American journal of medical genetics. Part A
- 1 October 2015
Hereditary nonsyndromic hearing loss is extremely heterogeneous. Mutations in the transmembrane channel‐like gene1 (TMC1) are known to cause autosomal dominant and recessive forms of nonsyndromic… Expand
Mechanism of juglone-induced apoptosis of MCF-7 cells by the mitochondrial pathway.
- Y. Ji, G. Xin, Z. Qu, X. Zou, M. Yu
- Chemistry, Medicine
- Genetics and molecular research : GMR
- 25 July 2016
This study investigated the nature and mechanism of juglone-induced apoptosis in the human breast cancer cell line MCF-7. The inhibitory effect of juglone on MCF-7 cell growth was evaluated by the… Expand
[Identification of metabolites of environmental hormone butylbenzyl phthalate in mice urine by liquid chromatography/ion trap mass spectrometry].
The metabolites of butylbenzyl phthalate in mice urine were identified by HPLC-MS(n). After the analysis of speculated metabolites and standard sample by HPLC-UV and the second full mass scanning… Expand
The effect of solanine on the membrane potential of mitochondria in HepG2 cells and [Ca2+]i in cells
To observe the effect of solanine on the membrane potential of mitochondria in HepG2 cells and [Ca2+]i in the cells, and to uncover the mechanism by which solanine induces apoptosis.HepG2 cells are… Expand