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Large-scale association analysis identifies new risk loci for coronary artery disease
TLDR
An association analysis in CAD cases and controls identifies 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants strongly associated with CAD at a 5% false discovery rate (FDR).
Randomized trial of stents versus bypass surgery for left main coronary artery disease.
TLDR
In this randomized trial involving patients with unprotected left main coronary artery stenosis, PCI with sirolimus-eluting stents was shown to be noninferior to CABG with respect to major adverse cardiac or cerebrovascular events, but the results cannot be considered clinically directive.
Stents versus coronary-artery bypass grafting for left main coronary artery disease.
TLDR
In a cohort of patients with unprotected left main coronary artery disease, there was no significant difference in rates of death or of the composite end point of death, Q-wave myocardial infarction, or stroke between patients receiving stents and those undergoing CABG, but stenting, even with drug-eluting stents, was associated with higher rates of target-vessel revascularization than was CABGs.
Metabolic profiling of plasma in overweight/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS).
TLDR
The amount of dietary saturated fat may influence the proportion of saturated fatty acids in serum phospholipids and the degree of saturation of the constituent acyl group of plasma lysoPC in overweight/obese men.
Six-Month Versus 12-Month Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stents: The Efficacy of Xience/Promus Versus Cypher to Reduce Late Loss After Stenting (EXCELLENT) Randomized,
TLDR
Six-month DAPT did not increase the risk of target vessel failure at 12 months after implantation of drug-eluting stents compared with 12-monthDAPT, however, the noninferiority margin was wide, and the study was underpowered for death or myocardial infarction.
Efficacy and Safety of Dual Antiplatelet Therapy After Complex PCI.
Adiponectin concentrations: a genome-wide association study.
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