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Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha
SummaryGenistein and apigenin are phytoestrogens present in commercial preparations used for the treatment of postmenopausal symptoms. In this study, we assessed the influence of these compounds onExpand
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Identification of the Tau phosphorylation pattern that drives its aggregation
Significance In Alzheimer’s disease, the microtubule-associated protein Tau is invariably found in a hyperphosphorylated and aggregated form. Whether (hyper)phosphorylation can drive aggregation isExpand
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Lack of sufficient information on the specificity and selectivity of commercial phytoestrogens preparations for therapeutic purposes.
Phytoestrogens (PEs) are polyphenols of plant origin among which flavones, flavanones, isoflavones, coumarins, chalcones, lignans and stilbenes are the best representatives. By interacting withExpand
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Interactions of isoflavones and other plant derived estrogens with estrogen receptors for prevention and treatment of breast cancer—Considerations concerning related efficacy and safety
  • G. Leclercq, Y. Jacquot
  • Medicine, Biology
  • The Journal of Steroid Biochemistry and Molecular…
  • 31 January 2014
Phytoestrogens are natural endocrine disruptors that interfere with estrogenic pathways. They insert directly within the hormone-binding domain of ERα and β, with a preference for the β isoform ofExpand
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The estrogen receptor alpha-derived peptide ERα17p (P(295)-T(311)) exerts pro-apoptotic actions in breast cancer cells in vitro and in vivo, independently from their ERα status.
In recent years, our knowledge on estrogen receptors (ER) has been modified profoundly with the identification and the deciphering of the role of its protein effectors, as well as with the deeperExpand
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Capacity of type I and II ligands to confer to estrogen receptor alpha an appropriate conformation for the recruitment of coactivators containing a LxxLL motif-Relationship with the regulation of
Estrogen receptor alpha (ERalpha) belongs to the superfamily of nuclear receptors and as such acts as a ligand-modulated transcription factor. Ligands elicit in ERalpha conformational changes leadingExpand
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Peptides targeting estrogen receptor alpha-potential applications for breast cancer treatment.
Activation of the estrogen receptor alpha (ERα) is of prime importance for the development of hormone-dependent breast cancers. Hence, drugs able to impede the emergence of an active folding of ERαExpand
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Analysis of the progesterone displacement of its human serum albumin binding site by beta-estradiol using biochromatographic approaches: effect of two salt modifiers.
The mechanisms of (i) the binding of two sex-hormones (i.e. progesterone and beta-estradiol) to human serum albumin (HSA) and (ii) the progesterone displacement of its HSA binding cavity byExpand
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Whole transcriptome analysis of the ERα synthetic fragment P295-T311 (ERα17p) identifies specific ERα-isoform (ERα, ERα36)-dependent and -independent actions in breast cancer cells.
ERα17p is a peptide corresponding to the sequence P295LMIKRSKKNSLALSLT311 of the estrogen receptor alpha (ERα) and initially found to interfere with ERα-related calmodulin binding. ERα17p wasExpand
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Biophysical studies of the interaction between calmodulin and the R 287-T 311 region of human estrogen receptor a reveals an atypical binding process
The transcriptional activity of human estrogen receptor ERa is modulated by a number of coregulatory proteins among which calmodulin (CaM). Segment 295–311 in the hinge region of ERa has previouslyExpand
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