Stability of curcumin in buffer solutions and characterization of its degradation products.
- Y. J. Wang, M. Pan, J. K. Lin
- Chemistry, MedicineJournal of Pharmaceutical and Biomedical Analysis
- 1 August 1997
Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane…
Results indicate that AN ingredients are crucial in the pathogenesis of oral submucous fibrosis (OSF) and oral cancer by differentially inducing the dysregulation of cell cycle control, Deltabetam, GSH level and intracellular H(2)O( 2) production, these events being not coupled with cellular apoptosis.
Areca nut extract up-regulates prostaglandin production, cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes.
The results suggest that AN ingredients are critical in the pathogenesis of oral submucous fibrosis and oral cancer via their stimulatory effects on the PGs, COX-2 production and associated tissue inflammatory responses.
Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells.
The results suggest that chemotherapeutic agents (such as ND) administered in the presence of GF might provide a novel therapy for colorectal cancer.
Oxidative stress and liver toxicity in rats and human hepatoma cell line induced by pentachlorophenol and its major metabolite tetrachlorohydroquinone.
- Y. J. Wang, C. C. Lee, W. Chang, H. Liou, Y. Ho
- Biology, ChemistryToxicology Letters
- 20 June 2001
Different cell death mechanisms and gene expression in human cells induced by pentachlorophenol and its major metabolite, tetrachlorohydroquinone.
- Y. J. Wang, Y. Ho, J. Jeng, H. Su, C. C. Lee
- BiologyChemico-Biological Interactions
- 1 November 2000
Reactive oxygen species are crucial for hydroxychavicol toxicity toward KB epithelial cells
- J. Jeng, Y. J. Wang, M. Chang
- Biology, ChemistryCellular and Molecular Life Sciences (CMLS)
Results indicate that HC consumption may be associated with BQ-chewing-related oral mucosal diseases via GSH depletion, ROS production, mitochondrial dysfunction, cell cycle disturbance and the induction of apoptosis.
Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging.
- Y. J. Wang, Y. Ho, M. Lo, J. K. Lin
- Biology, ChemistryChemico-Biological Interactions
- 1 February 1995
Induction of glutathione depletion, p53 protein accumulation and cellular transformation by tetrachlorohydroquinone, a toxic metabolite of pentachlorophenol.
Ketoconazole induces G0/G1 arrest in human colorectal and hepatocellular carcinoma cell lines.
The results revealed that ketoconazole-induced growth arrest was more profound in COLO 205 and Hep G2 than in HT 29 (p53 His(273) mutant) and Hep 3B (with deleted p53) cells, and suggested that the p53-associated signaling pathway is involved in the regulation ofketoconazoles-induced cancer cell growth arrest.