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A novel mechanism of myocyte degeneration involving the Ca2+-permeable growth factor–regulated channel
Disruption of the dystrophin–glycoprotein complex caused by genetic defects of dystrophin or sarcoglycans results in muscular dystrophy and/or cardiomyopathy in humans and animal models. However, theExpand
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Determination of salvinorin A and salvinorin B in Salvia divinorum-related products circulated in Japan.
Two major salvinorins, salvinorin A (SalA) and salvinorin B (SalB), in three Salvia divinorum dried leaf products and nine of its "concentrated extract" products circulated in Japan were determined.Expand
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Dominant-negative inhibition of Ca2+ influx via TRPV2 ameliorates muscular dystrophy in animal models.
Muscular dystrophy is a severe degenerative disorder of skeletal muscle characterized by progressive muscle weakness. One subgroup of this disease is caused by a defect in the gene encoding one ofExpand
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Blockade of sarcolemmal TRPV2 accumulation inhibits progression of dilated cardiomyopathy.
AIMS Dilated cardiomyopathy (DCM) is a severe disorder defined by ventricular dilation and contractile dysfunction. Abnormal Ca(2+) handling is hypothesized to play a critical pathological role inExpand
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Determination of muscimol and ibotenic acid in Amanita mushrooms by high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry.
A reliable analytical method was developed for the quantification and identification of muscimol (MUS) and ibotenic acid (IBO), the toxic constituents of Amanita muscaria and Amanita pantherina. MUSExpand
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Detection of main metabolites of XLR-11 and its thermal degradation product in human hepatoma HepaRG cells and human urine.
The metabolism of (1-(5-fluoropentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone (XLR-11), a novel synthetic cannabinoid, was studied using a HepaRG cell culture. The HepaRG cells wereExpand
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Time-course measurements of caffeine and its metabolites extracted from fingertips after coffee intake: a preliminary study for the detection of drugs from fingerprints
The aim of this study was to determine whether an ingested drug and its metabolites could be detected in the subject’s fingerprints. Caffeine (CF) was chosen as the model drug. Three healthy subjectsExpand
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Defective association of dystrophin with sarcolemmal glycoproteins in the cardiomyopathic hamster heart
In ventricular muscle from 30‐ to 60‐day‐old Bio 14.6 cardiomyopathic hamsters, dystrophin‐associated glycoproteins of 43, 50 and 150 kDa are markedly reduced in abundance. In particular, the 50‐kDaExpand
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In vitro stability and metabolism of salvinorin A in rat plasma
Salvinorin A is the main active psychoactive ingredient in Salvia divinorum, a Mexican plant that has been widely available as a hallucinogen in recent years. The aims of this study were toExpand
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Uptake of 3,4-methylenedioxymethamphetamine and its related compounds by a proton-coupled transport system in Caco-2 cells.
3,4-methylenedioxymethamphetamine (MDMA) is an illegal amphetamine-type stimulant (ATS) that is abused orally in the form of tablets for recreational purposes. The aim of this work is to investigateExpand
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