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Different inhibitory effect of fluvoxamine on omeprazole metabolism between CYP2C19 genotypes.
A potent inhibitory effect of fluvoxamine on CYP2C19 activity is confirmed and the bioavailability of omeprazole might, to some extent, be increased through inhibition of P-glycoprotein during fluv oxamine treatment. Expand
Effect of dose timing in relation to food intake on systemic exposure to blonanserin
Food intake increased the systemic exposure to blonanserin for all time intervals investigated in this study, and the marked effect of food on the bioavailability of blonANSerin should be taken into account in its dosing schedules. Expand
Interaction Between Paliperidone and Carbamazepine
It is suggested that adjunctive treatment with carbamazepine reduces the concentration of paliperidone in a dose-dependent manner, most likely because of the induction of several drug-metabolizing enzymes and several drug transporters. Expand
Alternative splicing variant of vascular endothelial growth factor-A is a critical prognostic factor in non-small cell lung cancer.
Multivariate analysis of the mRNA levels of 10 selected genes in 130 NSCLC specimens demonstrated highly significant co-expressions among the VEGF isoforms, and correlations among the prognosis, gene expressions, clinical factors, and pathological features using the Cox proportional hazards model were analyzed. Expand
A sensitive column-switching HPLC method for aripiprazole and dehydroaripiprazole and its application to human pharmacokinetic studies.
A simple and sensitive column-switching HPLC-UV method was developed for the simultaneous determination of aripiprazole, a novel atypical antipsychotic drug, and its active metabolite, dehydroaripipazole in human plasma and was applied to pharmacokinetic study in human volunteers and patients taking aripIPrazole. Expand
Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia.
The results suggest that specific cytokines, chemokines, and NK cells are involved in the pathogenesis of interstitial pneumonia and that the clinical use of this interleukin may result in unexpected physiological consequences. Expand
Effects of the CYP2D6*10 allele on the steady‐state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia
The CYP2D6*10 (*10) allele is present in Asians with a high frequency of about 50% and the effects of the *10 allele on the steady‐state plasma concentrations (Css) of haloperidol and reduced haloperIDol are studied. Expand
Bcl-2 overexpression enhances in vitro sensitivity against docetaxel in non-small cell lung cancer.
Positive Bcl-2 expression is a promising indicator in determining in vitro taxane sensitivity in NSCLCs and positive P-gp expression may be an indicator of enhanced in vitro resistance to CDDP in pulmonary adenocarcinomas. Expand
QT prolongation of the antipsychotic risperidone is predominantly related to its 9‐hydroxy metabolite paliperidone
A dose‐dependent increase in risk of sudden cardiac death for the antipsychotic drug risperidone was reported. However, few reports have so far addressed QT prolongation associated with the use ofExpand