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Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo.
Our aim was to determine whether a Vaccinium myrtillus (bilberry) anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) can protect retinal ganglionExpand
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Brazilian Green Propolis Protects against Retinal Damage In Vitro and In Vivo
Propolis, a honeybee product, has gained popularity as a food and alternative medicine. Its constituents have been shown to exert pharmacological (anticancer, antimicrobial and anti-inflammatory)Expand
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Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye.
The purpose of this study was to evaluate the potential of submicron-sized liposomes (ssLips) as a novel system for delivering ocular drugs to the eye's posterior segment. Fluorescence emission ofExpand
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Coenzyme Q10 protects retinal cells against oxidative stress in vitro and in vivo
PURPOSE To investigate the neuroprotective effects of coenzyme Q10 and/or a vitamin E analogue on retinal damage both in vitro and in vivo. METHODS We employed cultured retinal ganglion cellsExpand
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Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo.
We have investigated whether astaxanthin exerted neuroprotective effects in retinal ganglion cells in-vitro and in-vivo. In-vitro, retinal damage was induced by 24-h hydrogen peroxide (H2O2) exposureExpand
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Involvement of ER stress in retinal cell death
Purpose To clarify whether endoplasmic reticulum (ER) stress is involved in retinal cell death, using cultured retinal ganglion cells (RGC-5, a rat ganglion cell line transformed with E1A virus), andExpand
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Reduced retinal function in amyloid precursor protein‐over‐expressing transgenic mice via attenuating glutamate‐N‐methyl‐d‐aspartate receptor signaling
Here, we examined whether amyloid‐β (Aβ) protein participates in cell death and retinal function using three types of transgenic (Tg) mice in vivo [human mutant amyloid precursor protein (APP) Tg (TgExpand
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Role of endoplasmic reticulum stress in light‐induced photoreceptor degeneration in mice
Exposure to excessive levels of light induces photoreceptor apoptosis and can be a causative factor in age‐related macular degeneration (AMD). However, the cellular events that mediate this apoptoticExpand
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Role of oxidative stress in retinal photoreceptor cell death in N-methyl-N-nitrosourea-treated mice.
This study aimed to investigate whether oxidative stress contributes to retinal cell death in a mouse model of photoreceptor degeneration induced by N-methyl-N-nitrosourea (MNU). We measured in vitroExpand
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A Na+/Ca2+ exchanger isoform, NCX1, is involved in retinal cell death after N‐methyl‐D‐aspartate injection and ischemia–reperfusion
We investigated the expression of Na+/Ca2+ exchanger (NCX) and the functional role of NCX in retinal damage by using NCX1‐heterozygous deficient mice (NCX1+/−) and SEA0400Expand
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