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Human Keratinocytes That Express hTERT and Also Bypass a p16INK4a-Enforced Mechanism That Limits Life Span Become Immortal yet Retain Normal Growth and Differentiation Characteristics
TLDR
Keratinocyte replicative potential is limited by a p16INK4a-dependent mechanism, the activation of which can occur independent of telomere length, and abrogation of this mechanism together with telomerase expression immortalizes keratinocytes without affecting other major growth control or differentiation systems. Expand
Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas.
TLDR
Allelic loss (or loss of heterozygosity) of chromosome 1p is a statistically significant predictor of chemosensitivity, and combined loss involving chromosomes 1p and 19q is statistically significantly associated with both chemos sensitivity and longer recurrence-free survival after chemotherapy. Expand
Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors.
TLDR
It is demonstrated that autocrine TGF-beta signaling plays an essential role in retention of stemness of glioma-initiating cells (GICs) and the underlying mechanism for it is described, and an essential pathway for GICs is identified, the TGF/Sox4-Sox2 pathway, whose disruption would be a therapeutic strategy against gliomas. Expand
Oncolytic virus therapy: A new era of cancer treatment at dawn
TLDR
It appears that it will not be long before oncolytic virus therapy becomes a standard therapeutic option for all cancer patients, following the success in immunotherapy using immune checkpoint inhibitors. Expand
Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation.
TLDR
The findings suggest that CDKN2A/p16 inactivation occurs during the malignant transformation of NFs in NF1 patients and raises the possibility that p16 immunohistochemistry may provide ancillary information in the distinction of NF from MPNST. Expand
5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.
TLDR
It is suggested that 5hmC plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of cancer-related genes. Expand
Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis.
TLDR
The possibility that therapeutic decisions at the time of diagnosis might be tailored to particular genetic subtypes of anaplastic oligodendroglioma is raised, for the first time, in this group of patients in whom therapeutic management was not uniform. Expand
Glioma-initiating Cells Retain Their Tumorigenicity through Integration of the Sox Axis and Oct4 Protein*
TLDR
It is demonstrated that Oct4 plays essential roles in retention of the stemness properties of glioma-initiating cells through positive regulation of Sox2 expression, and this discovery uncovers the transcriptional network of stemness genes in cancer-in Initiating cells. Expand
Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier.
TLDR
It is likely that the selective and accelerated accumulation of cRGD/m into tumors occurred via an active internalization pathway, possibly transcytosis, thereby producing significant antitumor effects in an orthotopic mouse model of U87MG human glioblastoma. Expand
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