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A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice.
Acute and chronic experimental ulcerative colitis models were produced in mice by providing them with drinking water containing synthetic dextran sulfate sodium. Mice that developed acute colitisExpand
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Emerging insights into Transforming growth factor β Smad signal in hepatic fibrogenesis
Irrespective of initial stimuli, increased production of type I collagen is a common hallmark of fibrotic diseases in various organs including the liver. A dynamic balance between the production andExpand
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Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats
Background: Liver cirrhosis, which is caused by the accumulation of extracellular matrix materials, is a serious clinical problem that can progress to hepatic failure. Transforming growth factor-βExpand
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Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins
BackgroundConditional knockout mice and transgenic mice expressing recombinases, reporters, and inducible transcriptional activators are key for many genetic studies and comprise over 90% of mouseExpand
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Differential regulation of TGF‐β signal in hepatic stellate cells between acute and chronic rat liver injury
During chronic liver injury, transforming growth factor β (TGF‐β) plays a prominent role in stimulating liver fibrogenesis by myofibroblast‐like cells derived from hepatic stellate cells (HSCs). OnExpand
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Interferon-γ Interferes with Transforming Growth Factor-β Signaling through Direct Interaction of YB-1 with Smad3*
Transforming growth factor-β (TGF-β) and interferon-γ (IFN-γ) exert antagonistic effects on collagen synthesis in human dermal fibroblasts. We have recently shown that Y box-binding protein YB-1Expand
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Bone marrow–derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice
Liver fibrosis is usually progressive, but it can occasionally be reversible if the causative agents are adequately removed or if patients are treated effectively. However, molecular mechanismsExpand
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BMP-7 opposes TGF-beta1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2.
Mesenchymal cells, primarily fibroblasts and myofibroblasts, are the principal matrix-producing cells during pulmonary fibrogenesis. Transforming growth factor (TGF)-beta signaling plays an importantExpand
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Y-box-binding Protein YB-1 Mediates Transcriptional Repression of Human α2(I) Collagen Gene Expression by Interferon-γ*
We have demonstrated previously that a proximal element within the human α2(I) collagen gene (COL1A2) promoter mediates transcriptional repression by interferon-γ (IFN-γ), and designated this regionExpand
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p38 MAPK mediates fibrogenic signal through smad3 phosphorylation in rat myofibroblasts
Hepatic stellate cells (HSCs) spontaneously transdifferentiate into myofibroblast (MFB)‐phenotype on plastic dishes. This response recapitulates the features of activation in vivo. TransformingExpand
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