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Molecular characterization of tumors meeting diagnostic criteria for the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)
TLDR
T tumors fitting criteria for NIFTP are molecularly diverse, making it difficult to diagnose them with molecular studies, likely including matrial from cytopathology samples. Expand
Identification of novel targets of diabetic nephropathy and PEDF peptide treatment using RNA-seq
TLDR
The data suggest that mitochondrial dysfunction, genotoxicity and oxidative stress are principal events in DN and that P78-PEDF holds promise for its management. Expand
Environmental enrichment ameliorates perinatal brain injury and promotes functional white matter recovery
TLDR
Environmental enrichment is used to rescue white matter dysmaturation following hypoxia, while identifying a critical window of intervention and oligodendrocyte-specific changes in gene expression and indicating that myelin plasticity induced by modulation of the neonatal environment can be targeted as a therapeutic strategy for preterm birth. Expand
Targeting IDH1 as a Prosenescent Therapy in High-grade Serous Ovarian Cancer
TLDR
It is found that in comparison with normal fallopian tube epithelial cells, HGSC cells preferentially utilize glucose in the TCA cycle and not for aerobic glycolysis, which suggests that increased IDH1 activity is an important metabolic adaptation in HGSC and that targeting wild-type IDH3 alters the repressive histone epigenetic landscape to induce senescence. Expand
Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming
SUMMARY Reprogrammed metabolism and cell cycle dysregulation are two cancer hallmarks. p16 is a cell cycle inhibitor and tumor suppressor that is upregulated during oncogene-induced senescence (OIS).Expand
Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy
TLDR
Data show that TRPM2 has an important role in AML proliferation and survival through regulation of key transcription factors and target genes involved in mitochondrial function, bioenergetics, the antioxidant response, and autophagy. Expand
Association of frequent genetic variants in platelet activation pathway genes with large-vessel ischemic stroke in Polish population
TLDR
The results of the study demonstrate statistically significant differences in two frequent intronic genetic variants (in RGS7 and ANKS1B) that could be associated with the platelet function between ischemic stroke patients with coexisting large-vessel atherosclerosis and control patients having high vascular risk. Expand
Suppression of p16 increases nucleotide synthesis via mTORC1
TLDR
It is reported that suppression of p16 plays a central role in reprogramming metabolism by increasing nucleotide synthesis via Ataxia Telangiectasia and Rad3-Related Protein activation of mTORC1 signaling, which mediated increased translation of the mRNA encoding ribose-5-phosphate isomerase A, a pentose phosphate pathway enzyme. Expand
WDR68 is essential for the transcriptional activation of the PRC1-AUTS2 complex and neuronal differentiation of mouse embryonic stem cells.
TLDR
It is demonstrated that WDR68 is not only an integral component of the PRC1-AUTS2 complex, but it is also required for PRC 1- AUTS2-mediated transcription activation, and many genes responsible for neuronal differentiation are down-regulated in Wdr68 deficient neural progenitors. Expand
Placental endocrine function shapes cerebellar development and social behavior
TLDR
It is shown that placenta allopregnanolone (ALLO), a progesterone-derived GABA-A receptor (GABAAR) modulator, reduction alters neurodevelopment in a sex- linked manner, revealing a new role for a placental hormone in shaping brain regions and behaviors in asex-linked manner. Expand
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