• Publications
  • Influence
Synfire Chains and Cortical Songs: Temporal Modules of Cortical Activity
  • Y. Ikegaya, Gloster Aaron, +4 authors R. Yuste
  • Computer Science, Biology
  • Science
  • 23 April 2004
TLDR
We find precise repetitions of spontaneous patterns of synaptic inputs in neocortical neurons in vivo and in vitro. Expand
  • 766
  • 41
  • PDF
Locally Synchronized Synaptic Inputs
Coordinating Synapses Cortical microcircuits produce cell assemblies that emit spatiotemporally orchestrated spiking activity. These activity patterns are decoded by the dendrites of downstreamExpand
  • 248
  • 23
  • PDF
Large-Scale Calcium Waves Traveling through Astrocytic Networks In Vivo
Macroscopic changes in cerebral blood flow, such as those captured by functional imaging of the brain, require highly organized, large-scale dynamics of astrocytes, glial cells that interact withExpand
  • 204
  • 16
  • PDF
Activity-Evoked Capacitative Ca2+ Entry: Implications in Synaptic Plasticity
The Ca2+ influx controlled by intracellular Ca2+ stores, called store-operated Ca2+ entry (SOC), occurs in various eukaryotic cells, but whether CNS neurons are endowed with SOC capability and howExpand
  • 164
  • 15
  • PDF
Brain-Derived Neurotrophic Factor Promotes the Maturation of GABAergic Mechanisms in Cultured Hippocampal Neurons
Brain-derived neurotrophic factor (BDNF) has been implicated in activity-dependent plasticity of neuronal function and network arrangement. To clarify how BDNF exerts its action, we evaluated theExpand
  • 200
  • 14
Action-Potential Modulation During Axonal Conduction
The waveform of an action potential can be physiologically modified while it travels along the axon. Once initiated near the soma, an action potential (AP) is thought to propagate autoregenerativelyExpand
  • 174
  • 13
  • PDF
Genetically Encoded Green Fluorescent Ca2+ Indicators with Improved Detectability for Neuronal Ca2+ Signals
Imaging the activities of individual neurons with genetically encoded Ca2+ indicators (GECIs) is a promising method for understanding neuronal network functions. Here, we report GECIs with improvedExpand
  • 178
  • 12
  • PDF
Fast and accurate detection of action potentials from somatic calcium fluctuations.
TLDR
We propose a novel automatic method that combines principal-component analysis and support vector machine. Expand
  • 133
  • 12
  • PDF
Hippocampal ripples down-regulate synapses
Rebalancing mechanisms during sleep Synapses are often strengthened during wake periods and thus need to be homeostatically readjusted during sleep. During slow-wave sleep, synaptic depression isExpand
  • 82
  • 12
  • PDF
Metastability of Active CA3 Networks
The brain is spontaneously active even in the absence of external input. This ongoing background activity impacts neural information processing. We used functional multineuron calcium imaging (fMCI)Expand
  • 165
  • 10
  • PDF