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Synfire Chains and Cortical Songs: Temporal Modules of Cortical Activity
TLDR
This work finds precise repetitions of spontaneous patterns of synaptic inputs in neocortical neurons in vivo and in vitro, which repeat after minutes, maintaining millisecond accuracy.
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Locally Synchronized Synaptic Inputs
TLDR
Clustered synaptic plasticity is innately programmed to compartmentalize correlated inputs along dendrites and may reify nonlinear synaptic integration.
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Brain-Derived Neurotrophic Factor Promotes the Maturation of GABAergic Mechanisms in Cultured Hippocampal Neurons
TLDR
It is shown that BDNF facilitates high K+-elicited release of GABA but not of glutamate and induces an increase in immunoreactive signals of glutamic acid decarboxylase, a GABA-synthesizing enzyme, which indicates that it principally promotes GABAergic maturation but may also potentially contribute to excitatory synapse development via increasing resting synaptic vesicles.
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Large-Scale Calcium Waves Traveling through Astrocytic Networks In Vivo
TLDR
Almost all astrocytes participated en masse in regenerative waves that propagated from cell to cell (referred to here as “glissandi”) and emerged depending on the neuronal activity and accompanied a reduction in infraslow fluctuations of local field potentials and a decrease in the flow of red blood cells.
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Activity-Evoked Capacitative Ca2+ Entry: Implications in Synaptic Plasticity
TLDR
Using Ca2+ imaging, evidence is presented for the presence of SOC in cultured hippocampal pyramidal neurons and a novel link between ionotropic receptor-activated SOC and neuroplasticity is suggested.
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Genetically Encoded Green Fluorescent Ca2+ Indicators with Improved Detectability for Neuronal Ca2+ Signals
TLDR
GECIs with improved neuronal Ca2+ signal detectability, termed G-CaMP6 and G- CaMP8, are reported, which could detect individual spikes from pyramidal neurons of cultured hippocampal slices or acute cortical slices with 100% detection rates.
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An Improved Genetically Encoded Red Fluorescent Ca2+ Indicator for Detecting Optically Evoked Action Potentials
TLDR
An improved red fluorescent GECI is developed, termed R-CaMP1.07, by mutagenizing R-GECO1.
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Action-Potential Modulation During Axonal Conduction
TLDR
The waveform of an action potential can be physiologically modified while it travels along the axon, and this local AP modification may enable axonal computation through the geometry of axon wiring.
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Metastability of Active CA3 Networks
TLDR
Functional multineuron calcium imaging data suggest that the network states are metastable, rather than multistable, and might be governed by local attractor-like dynamics.
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Interpyramid spike transmission stabilizes the sparseness of recurrent network activity.
TLDR
It is proposed that an unequally biased distribution with a few select strong synapses helps stabilize sparse neuronal activity, thereby reducing the total spiking cost, enhancing the circuit responsiveness, and ensuring reliable information transfer.
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