Share This Author
Structures of enzymatically modified products of arbekacin by methicillin-resistant. Staphylococcus aureus.
- S. Kondo, A. Tamura, S. Gomi, Y. Ikeda, T. Takeuchi, S. Mitsuhashi
- Biology, ChemistryThe Journal of antibiotics
- 25 February 1993
Only a limited number of strains of methicillin-resistant Staphylococcus aureus (MRSA) moderately resistant to arbekacin (ABK) have been isolated clinically and the structures of these modification products were determined by MS and NMR spectral analyses.
Inhibition of Acidic Sphingomyelinase by Xanthone Compounds Isolated from Garcinia Speciosa
Three xanthone compounds isolated from the bark of Garcinia speciosa competitively inhibited bovine brain-derived acidic sphingomyelinase with IC50 values of 14.1, 19.2, and 10.9 μM and α-Mangostin was chemically modified and its structure-activity relationships are discussed.
Inhibition of Lipopolysaccharide Activity by a Bacterial Cyclic Lipopeptide Surfactin
Surface plasmon resonance (SPR) analysis revealed the surfactin to interact reversibly with lipid A, and this Bacillus surfactIn was shown to be an inhibitor of LPS-induced signal transduction, directly interacting with LPS.
A new trisaccharide, α-d-glucopyranuronosyl-(1→3)-α-l-rhamnopyranosyl-(1→2)-α-l-rhamnopyranose from Chlorella vulgaris
Structure of an antitumor antibiotic, spergualin.
A new antibiotic, negamycin.
Safracins, new antitumor antibiotics. II. Physicochemical properties and chemical structures.
The chemical structures of safracins A and B are proposed to be 1 and 2 respectively on the basis of their physiocochemical properties and spectrometric studies.
Polyoxypeptins A and B Produced by Streptomyces: Apoptosis-Inducing Cyclic Depsipeptides Containing the Novel Amino Acid (2S,3R)-3-Hydroxy-3-methylproline.
- K. Umezawa, K. Nakazawa, Y. Ikeda, H. Naganawa, S. Kondo
- Chemistry, BiologyThe Journal of organic chemistry
- 7 April 1999
Potent apoptosis-inducing peptides, polyoxypeptins A (1) and B (2) were isolated from the culture broth of Streptomyces sp. by solvent extraction and column chromatography. Structural elucidation of…
[Susceptibility of methicillin-resistant Staphylococcus aureus to various antibiotics. Classification by aminoglycoside-modifying enzymes and antibiotics active against MRSA].
- S. Kondo, Y. Ikeda, S. Hattori, M. Hamada, T. Takeuchi
- Biology, MedicineThe Japanese journal of antibiotics
- 1 November 1991
MICs of 14 aminoglycoside antibiotics including 10 of those used clinically were determined against 50 strains of methicillin-resistant Staphylococcus aureus which had been isolated at a hospital in Osaka between 1986 and 1990, finding 13 known antibiotics were found active against MRSA upon random screening.
Enzymatic 2'-N-acetylation of arbekacin and antibiotic activity of its product.
It is believed 2'-N-acetyl ABK has the highest and broadest antibacterial activity, compared with known N- acetylated AGs.