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Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells.
It was found that the expression of xCT was rapidly induced in U87 cells upon oxidative stress by diethyl maleate treatment, which was accompanied by the increase in the L-cystine uptake by U 87 cells, indicating the association of two proteins via disulfide bands. Expand
beta-hydroxyisovalerylshikonin inhibits the cell growth of various cancer cell lines and induces apoptosis in leukemia HL-60 cells through a mechanism different from those of Fas and etoposide.
The results indicate that beta-HIVS induces apoptosis in HL-60 cells through a mechanism unlike those reported for anti-Fas antibodies and etoposide. Expand
Terpenoids of Alisma orientale rhizome and the crude drug alismatis rhizoma
Abstract From fresh rhizome of Alisma orientale, and the crude drug Alismatis rhizoma of Japanese and Chinese origins, 15 new terpenoids were isolated together with 11 known terpenoids and wereExpand
Oleanolic acid saponins from root bark of Aralia elata.
Three new oleanolic acid glycosides, tarasaponins I-III, were isolated as their methyl esters from the root bark of Aralia elata together with four known glycosides, the methyl esters ofExpand
Studies on the constituents of the bark of Kalopanax pictus Nakai.
Five new compounds, kalopanaxsaponin G (2) and kalopanaxins A (6), B (8), C (11) and D (13), were isolated from the bark of Kalopanax pictus together with nine known compounds, kalopanaxsaponins AExpand
Comparative Studies on the Constituents of Ophiopogonis Tuber and Its Congeners. III. Studies on the Constituents of the Subterranean Part of Ophiopogon ohwii OKUYAMA and O. jaburan (KUNTH) LODD.
Six steroidal glycosides, tentatively named glycosides O-1, O-2 (1), O-3 (2), O-4 (3), O-5 (4) and O-6 (5), were isolated from the subterranean part of Ophiopogon ohwii OKUYAMA (Liliaceae) andExpand
Gastroprotective effects of bitter principles isolated from Gentian root and Swertia herb on experimentally-induced gastric lesions in rats
The results suggest that the therapeutic effects of Gentian root on gastric lesions are associated with enhanced mucosal defensive factors via the prostaglandin pathway in the cell membrane, and that secoiridoid glycosides contribute to this activity. Expand
Six new triterpenoidal glycosides including two new sapogenols from Albizziae Cortex. V.
Six new triterpenoid glycosides called julibrosides A1-A4, B1 and C1 were isolated from Albizziae Cortex, the dried stem bark of Albizzia julibrissin Durazz. Their structures were determined based onExpand
Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase.
Sessiloside and chiisanoside inhibited pancreatic lipase activity in vitro, and addition of the saponin-rich fraction to a high-fat diet suppressed the body weight gain of mice. Expand
Specific inhibition of hypoxia-inducible factor (HIF)-1 alpha activation and of vascular endothelial growth factor (VEGF) production by flavonoids.
Screening using a reporter under the control of the hypoxia-response element identified several flavonoids and homoisoflavonoids that inhibit the activation of HRE under hypoxic conditions and MOB is expected to act as an inhibitor of angiogenesis. Expand