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Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients
It is concluded that lymphocyte egress is mediated by S 1P gradients that are established by S1P lyase activity and that the lyase may represent a novel immunosuppressant drug target. Expand
Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
Separate sources provide S1P to plasma and lymph to help lymphocytes exit the low-S1P environment of lymphoid organs, and disruption of compartmentalized S 1P signaling is a plausible mechanism by which S1p-receptor-1 agonists function as immunosuppressives. Expand
3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone
The discovery of 3-iodothyronamine (T1AM), a naturally occurring derivative of TH that in vitro is a potent agonist of the G protein–coupled trace amine receptor TAR1, suggests the existence of a new signaling pathway, stimulation of which leads to rapid physiological and behavioral consequences that are opposite those associated with excess TH. Expand
Oxidative Stress in Parkinson's Disease
Should a similar multifactorial cascade underlie dopaminergic neuron degeneration in PD, then the optimal therapy for this disease may have to rely on a cocktail of agents, each targeting a different critical component of this hypothesized pathogenic cascade. Expand
Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism.
The ability of microbially derived metabolites to regulate or modify central and hepatic circadian rhythm and host metabolic function, the latter following intake of a Westernized diet is underscored. Expand
The kinase domain of mitochondrial PINK1 faces the cytoplasm
It is shown that this mitochondrial protein exhibits a topology in which the kinase domain faces the cytoplasm and the N-terminal tail is inside the mitochondria, and although deletion of the transmembrane domain disrupts this topology, common PD-linked PINK1 mutations do not. Expand
Effect of meteorological variables on the incidence of hand, foot, and mouth disease in children: a time-series analysis in Guangzhou, China
BackgroundOver the last decade, major outbreaks of hand, foot, and mouth disease (HFMD) have been reported in Asian countries, resulting in thousands of deaths among children. However, less is knownExpand
Spatial-Temporal Clusters and Risk Factors of Hand, Foot, and Mouth Disease at the District Level in Guangdong Province, China
The findings showed a strong association between HFMD and meteorological factors, which may assist in predicting HFMD incidence and children years old were more susceptible to HFMD. Expand
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.
A three-stage genome-wide association study to identify additional common variants associated with susceptibility and ultimately mortality in Idiopathic pulmonary fibrosis and novel variants in TOLLIP and SPPL2C are associated with IPF susceptibility. Expand
The Loop Position of shRNAs and Pre-miRNAs Is Critical for the Accuracy of Dicer Processing In Vivo
This work found that, in cells, Dicer induced imprecise cleavage events around the expected sites based on the previously described 5'/3' counting rules, and observed that the ~1/3 of mammalian endogenous pre-miRNAs that contained such structures were more precisely processed by Dicer. Expand