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Forgetting Is Regulated through Rac Activity in Drosophila
TLDR
It is reported that a small G protein Rac-dependent forgetting mechanism contributes to both passive memory decay and interference-induced forgetting in Drosophila and suggested that Rac's role in actin cytoskeleton remodeling may contribute to memory erasure. Expand
Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease
TLDR
It is postulate that aside from dysbiosis of the gut microbiota, gut microbiota-mediated inflammation of the intestinal mucosa and the related impairment in mucosal immune function play an important role in the pathogenesis of NAFLD. Expand
Development of PD-1/PD-L1 Pathway in Tumor Immune Microenvironment and Treatment for Non-Small Cell Lung Cancer
TLDR
The basic principle of PD-1/PD-L1 pathway and its role in the tumorigenesis and development of NSCLC is discussed and the main problems in the present studies and the research direction in the future will be discussed. Expand
Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations.
TLDR
These results strongly support a role of DRD2 as a susceptibility gene with heroin dependence in Chinese patients and was associated with low risk ofHeroin dependence in Germans. Expand
Donor-specific anti-HLA Abs and graft failure in matched unrelated donor hematopoietic stem cell transplantation.
TLDR
The presence of anti-DPB1 DSAs is associated with graft failure in MUD hematopoietic stem cell transplantation in patients with matched unrelated donor (MUD) transplantation. Expand
Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes
TLDR
In summary, overexpression of Dsg2 in epidermal keratinocytes deregulates multiple signaling pathways associated with increased growth rate, anchorage-independent cell survival, and the development of skin tumors in vivo. Expand
Apoptosis induction in human lung adenocarcinoma cells by oil‐soluble allyl sulfides: Triggers, pathways, and modulators
TLDR
It is reported that OASs DADS and DATS induce significant apoptosis in human lung adenocarcinoma A549 cells, whereas DAS does not, and the first evidence that Fas‐ mediated cell death pathway is partly involved in DADS but not DATS‐mediated cell death is provided. Expand
Saponins in the genus Panax L. (Araliaceae): a systematic review of their chemical diversity.
TLDR
This comprehensive review describes the advances in the phytochemistry of the genus Panax for the period 1963-2012, based on the 134 cited references, with special attention being paid to the structural features of the six different subtypes. Expand
Mesenchymal stem cells deliver exogenous miR‐21 via exosomes to inhibit nucleus pulposus cell apoptosis and reduce intervertebral disc degeneration
TLDR
MSC‐derived exosomes prevent NPCs from apoptotic process and alleviate IVD degeneration, at least partly, via miR‐21 contained in exosome. Expand
Circular RNA VMA21 protects against intervertebral disc degeneration through targeting miR-200c and X linked inhibitor-of-apoptosis protein
TLDR
CircVMA21 could alleviate inflammatory cytokines-induced NP cell apoptosis and imbalance between anabolism and catabolism of extracellular matrix through miR-200c-XIAP pathway and provides a potentially effective therapeutic strategy for IVDD. Expand
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