FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor…
A novel antitumor bicyclic depsipeptide, FR901228, was isolated from a broth culture of Chromobacterium violaceum No. 968 as colorless prisms and the molecular formula was determined as C24H36N4O6S2.…
Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968, on Ha-ras transformed NIH3T3 cells.
- H. Ueda, H. Nakajima, Y. Hori, T. Goto, M. Okuhara
- BiologyBioscience, biotechnology and biochemistry
- 23 September 1994
FR901228, a novel antitumor antibiotic, reversed the transformed morphology of the Ha-ras transformants, Ras-1 cells, and inhibited their growth, and was correlated with growth inhibition (G0/G1 arrest in cell cycle).
Isolation and some characterization of the prothoracicotropic hormone from Bombyx mori.
FR901469, a novel antifungal antibiotic from an unidentified fungus No.11243. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological properties.
It is shown that FR901469 inhibited the activity of 1,3-beta-glucan synthase from Candida albicans with an IC50 value of 0.05 microg/ml, and displayed greater inhibitory activity than other 1, 3- beta-gluca synthase inhibitors such as, WF11899A, echinocandin B, aculeacin A, and papulacandin A.
Chemical diversity in lipopeptide antifungal antibiotics
In the course of screening for antifungal antibiotics, we have discovered a novel series of lipopeptide compounds structurally related to, but highly superior to, echinocandin B in terms of their…
FR227673 and FR190293, Novel Antifungal Lipopeptides from Chalara sp. No. 22210 and Tolypocladium parasiticum No. 16616
Novel antifungal lipopeptides, FR227673 and FR190293, were isolated from the fermentation broths of fungal strains Chalara sp. No. 22210 and Tolypocladium parasiticum No. 16616, respectively. These…
New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action.
The results suggest that FR901464 may induce a dynamic change of chromatin structure, giving rise to strong antitumor activity, and therefore may represent a new type of drug for cancer chemotherapy.
A new antimitotic substance, FR182877. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
Structural studies on FR182877 suggested that it had a unique hexacyclic structure encompassing its highly strained double bond, which exhibited potent antitumor activities against murine ascitic tumor and solid tumor in vivo.
FR131535, a novel water-soluble echinocandin-like lipopeptide: synthesis and biological properties.
FR220897 and FR220899, Novel Antifungal Lipopeptides from Coleophoma empetri No. 14573
Novel antifungal lipopeptides, FR220897 and FR220899, were isolated from the fermentation broth of a fungal strain No. 14573 and showed antif fungus activities against Aspergillus fumigatus and Candida albicans attributed to inhibition of 1-3-β-glucan synthesis.