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The Drosophila mushroom body is a quadruple structure of clonal units each of which contains a virtually identical set of neurones and glial cells.
It is shown that the four mushroom body neuroblasts (MBNbs) give birth exclusively to the neurones and glial cells of the MB, and that each of the four MBNb clones contributes to the entire MB structure. Expand
sprouty Encodes a Novel Antagonist of FGF Signaling that Patterns Apical Branching of the Drosophila Airways
An antagonist of FGF signaling that patterns apical branching of the Drosophila airways is described and sprouty encodes a novel cysteine-rich protein that defines a new family of putative signaling molecules that may similarly function as FGF antagonists in vertebrate development. Expand
The drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates
Results show that svp is involved in control of cell fate during the generation of neuronal diversity and is likely to be a Drosophila homolog of the human transcription factor COUP. Expand
Local caspase activity directs engulfment of dendrites during pruning
- D. Williams, S. Kondo, A. Krzyzanowska, Y. Hiromi, J. Truman
- Chemistry, Medicine
- Nature Neuroscience
- 1 October 2006
It is shown that the removal of sensory neuron dendrites during pruning in Drosophila melanogaster is directed by local caspase activity, which is confined to the degenerating dendrite of pruning neurons. Expand
DRONC Coordinates Cell Death and Compensatory Proliferation
- S. Kondo, N. Senoo-Matsuda, Y. Hiromi, M. Miura
- Biology, Medicine
- Molecular and Cellular Biology
- 1 October 2006
The results show that the apoptotic pathway bifurcates at DRONC and thatDRONC coordinates the execution of cell death and compensatory proliferation, which suggests that compensatoryiferation is induced by dying cells as part of the apoptosis program. Expand
seven-up Controls switching of transcription factors that specify temporal identities of Drosophila neuroblasts.
Lineage analysis provides evidence that svp is required to switch off HB at the proper time, and modifies the self-renewal stem cell program to allow chronological change of cell fates, thereby generating neuronal diversity. Expand
Translational repression determines a neuronal potential in Drosophila asymmetric cell division
Cell-type-specific translational control of ttk69 by MSI is defined as a downstream event of Notch signalling in asymmetric cell division, which is likely to regulate MSI activity rather than its expression. Expand
Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila.
The results suggest that Sprouty acts as an antagonist of EGF as well as FGF signaling pathways, suggesting that receptor tyrosine kinase-mediated pathways may share not only intracellular signaling components but also extracellular factors that modulate the strength of the signal. Expand
Regulation and function of the Drosophila segmentation gene fushi tarazu
Fusion of the upstream element to a basal promoter results in activation of the heterologous promoter in a ftz-dependent striped pattern, supporting the idea that ftz regulates itself by acting through its enhancer. Expand
Control elements of the Drosophila segmentation gene fushi tarazu
C cis-acting controlling sequences of the ftz gene are analyzed by germ line transformation to identify morphogenetic controlling elements within the 5'-flanking sequences. Expand