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Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
The cardiac homeobox protein Nkx2-5 is essential in cardiac development, and mutations in Csx (which encodes Nkx2-5) cause various congenital heart diseases. Using the yeast two-hybrid system withExpand
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Smads, Tak1, and Their Common Target Atf-2 Play a Critical Role in Cardiomyocyte Differentiation
We previously demonstrated that bone morphogenetic proteins (BMPs) induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1. Transcription factors SmadsExpand
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Notch1 in Bone Marrow–Derived Cells Mediates Cardiac Repair After Myocardial Infarction
Background— The signaling mechanisms that regulate the recruitment of bone marrow (BM)–derived cells to the injured heart are not well known. Notch receptors mediate binary cell fate determinationExpand
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Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins 1
Anchoring proteins to cell surface membranes by glycosylphosphatidylinositols (GPIs) is important. We have isolated a component of the putative transamidase machinery, hGaa1p (human GPI anchorExpand
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Proprotein interaction with the GPI transamidase
For characterizing how the glycosylphosphatidylinositol (GPI) transamidase complex functions, we exploited a two‐step miniPLAP (placental alkaline phosphatase) in vitro translation system. With thisExpand
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Norepinephrine Induces the raf-1 Kinase/Mitogen-Activated Protein Kinase Cascade Through Both α1- and β-Adrenoceptors
Background Although norepinephrine induces cardiac hypertrophy by activating protein kinase A and C through β- and α 1 -adrenoceptors, respectively, protein kinase A has been reported to inhibit cellExpand
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Novel TBX5 mutations and molecular mechanism for Holt-Oram syndrome
The Holt-Oram syndrome (OMIM 142900) is an autosomal dominant disorder with clinical features characterised by a variety of skeletal malformations and congenital heart defects.1–5 The gene forExpand
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Two distinct mechanisms of angiotensin II-induced negative regulation of the mitogen-activated protein kinases in cultured cardiac myocytes.
Increasing evidence has suggested that mitogen-activated protein kinases (MAPKs) play important roles in the development of cardiac hypertrophy. We and others have reported that the activity of MAPKsExpand
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Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice.
BACKGROUND Rho-associated kinases (ROCK1 and ROCK2) are important regulators of the actin cytoskeleton and endothelial nitric oxide synthase (eNOS). Because the phosphorylation of eukaryoticExpand
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Cloning of murine glycosyl phosphatidylinositol anchor attachment protein, GPAA1.
Glycosyl phosphatidylinositols (GPIs) are used to anchor many proteins to the cell surface membrane and are utilized in all eukaryotic cells. GPI anchoring units are attached to proteins via aExpand
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