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Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities
Quinazoline alkaloid, vasicinone, showed a vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta and a moderate in vitro antiplasmodial activity against Plasmodium falciparum.
Studies on the constituents from the fruits of Phaleria macrocarpa
From the fruits of Phaleria macrocarpa, icariside C3 (1), phalerin (2), and mangiferin (3) were isolated and their structures were identified on the basis of spectroscopic data. Icariside C3 (1)…
Ceramicines B-D, new antiplasmodial limonoids from Chisocheton ceramicus.
Vasorelaxant effect of FR900359 from Ardisia crenata on rat aortic artery
- Kazumasa Zaima, Jun Deguchi, Yosuke Matsuno, Toshio Kaneda, Y. Hirasawa, H. Morita
- Biology, ChemistryJournal of Natural Medicines
The results suggest that the vasorelaxant effect of FR900359 is mediated through the increased release of NO from endothelium-intact aortic cells at low concentrations, and can be attributed to inhibitory effects on voltage-dependent Ca2+ channel- and receptor-operated Ca2- channel-dependentCa2+ influx at high concentrations.
Sieboldine A, a novel tetracyclic alkaloid from Lycopodium sieboldii, inhibiting acetylcholinesterase.
Sieboldine A (1) exhibited a potent inhibitory activity against acetylcholinesterase and modest cytotoxicity and the structure and relative stereochemistry were elucidated on the basis of 2D NMR data and X-ray analysis.
Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter.
New phlegmarane-type, cernuane-type, and quinolizidine alkaloids from two species of Lycopodium
Bisnicalaterine A, a vobasine-vobasine bisindole alkaloid from Hunteria zeylanica.
Bisnicalaterine A showed moderate cytotoxicity against various human cancer cell lines and its structures were elucidated on the basis of spectroscopic data and chemical correlation.
Gneyulins A and B, stilbene trimers, and noidesols A and B, dihydroflavonol-C-glucosides, from the bark of Gnetum gnemonoides.
Two new stilbene trimers consisting of oxyresveratrol constituent units and two new dihydroflavonol-C-glucosides were isolated from the bark of Gnetum gnemonoides and showed inhibition of Na(+)-glucose transporters.