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Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy.
TLDR
The results indicate that the decreased sialylation and galactosylation of the IgA1 hinge glycopeptides play a crucial role in its glomerular deposition in IgAN. Expand
Accumulation of Bisphenol A in Hemodialysis Patients
TLDR
Among renal disease patients who had not undergone hemodialysis, the serum BPA concentration increased as the renal function deteriorated, showing a significant negative association with BPA. Expand
Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins.
TLDR
The results indicated that the removal of carbohydrates from the IgA1 molecule resulted in noncovalent self-aggregation and a significant increase in adhesion to the ECM proteins. Expand
Analyses of IgA1 hinge glycopeptides in IgA nephropathy by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
TLDR
The results suggested the presence of a defect in the Gal and/or GalNAc residues in the IgA1 hinge glycopeptides in IgAN. Expand
Serum under-galactosylated IgA1 is increased in Japanese patients with IgA nephropathy.
TLDR
HAA-IgA binding is significantly increased in Japanese IgAN patients and the O-glycan structure of IgA1 hinge glycopeptides was shifted to smaller molecular weights in high HAA- IgA-binding IgAN Patients. Expand
Effective Antibiotic Treatment of Methicillin-Resistant Staphylococcus aureus-Associated Glomerulonephritis
TLDR
The results suggested that MRSA-associated glomerulonephritis might respond to antibiotic treatment in most cases, and indicated that special care must be taken in the application of steroid therapy for the glomersul onephritis with crescents, even though the MRSA infection has gone into an inactive state. Expand
Determination of Aberrant O-Glycosylation in the IgA1 Hinge Region by Electron Capture Dissociation Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry*
TLDR
Results represent the first direct identification of multiple sites of O-glycan attachment in IgA1 hinge region by mass spectrometry, thereby enabling future characterization at the molecular level of aberrant glycosylation of IgA 1 in diseases such as IgA nephropathy. Expand
Comparison of Methods for Profiling O-Glycosylation
TLDR
An assessment of the methodologies currently used for O-glycan analysis found two general strategies were found to give the most reliable data, namely direct MS analysis of mixtures of permethylated reduced glycans in the positive ion mode and analysis of native reduced glycoproteins in the negative ion mode using LC-MS approaches. Expand
Evidence for involvement of IgA1 hinge glycopeptide in the IgA1-IgA1 interaction in IgA nephropathy.
TLDR
The results suggested that the IgA 1-IgA1 interaction could be mediated by the core structure including the peptide and the sugars, except for sialic acid in the hinge region, resulting in the formation of the circulating macromolecular IgA1 in IgA nephropathy. Expand
PPAR-gamma agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease.
TLDR
It is determined that pioglitazone (PIO), a PPAR-γ agonist, decreases polycystic kidney and liver disease progression in the polycytic kidney rat, an orthologous model of human ARPKD, and suggest that PPAR -γ agonists may have therapeutic value in the treatment of the renal and hepatic manifestations of AR PKD. Expand
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