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Structure of a lipid intermediate in cell wall peptidoglycan synthesis: a derivative of a C55 isoprenoid alcohol.
TLDR
The purpose of the present paper is to report that lipid-P- P-disaccharide-pentapeptide has been obtained in a highly purified form from Mlicrococcus lysodeikticus, and that the nature of the lipid moiety of this intermediate has beeln elucidated. Expand
Evidence for a one-hit theory in the immune bactericidal reaction and demonstration of a multi-hit response for hemolysis by streptolysin O and Clostridium perfringens theta-toxin
TLDR
An analytical method was developed for estimating the number of hits necessary to lyse or kill cells in which various concentrations of the cells are treated with a constant amount of the lytic or killing agent in a constant reaction volume and it was clearly shown that immune bactericidal reactions followed a one-hit theory. Expand
Complementation characteristics of newly isolated mutants from two groups of strains of Clostridium perfringens.
TLDR
The result was that the resulting b group mutants could not produce the marker products that had been lost on the first NG treatment but could produce the others by complementation. Expand
Biosynthesis of the peptidoglycan of bacterial cell walls. XXI. Isolation of free C55-isoprenoid alcohol and of lipid intermediates in peptidoglycan synthesis from Staphylococcus aureus.
TLDR
The lipid intermediate, disaccharide (-pentapeptide)-P-P-lipid, has been isolated from Staphylococcus aureus and contains two internal trans double bonds, and it can be separated from C55-ficaprenol by reverse phase chromatography. Expand
Biosynthesis of the peptidoglycan of bacterial cell walls. XX. Identification of phosphatidylglycerol and cardiolipin as cofactors for isoprenoid alcohol phosphokinase.
Abstract The butanol-soluble long chain isoprenoid alcohol phosphokinase from Staphylococcus aureus has been separated into a protein and phospholipid component by chromatography on a column ofExpand
Biosynthesis of the peptidoglycan of bacterial cell walls. XIX. Isoprenoid alcohol phosphokinase.
TLDR
The presence of this enzyme and of C55-isoprenoid alcohol in S. aureus accounts for the stimulation by ATP of peptidoglycan synthesis catalyzed by particulate enzyme from this organism. Expand
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