• Publications
  • Influence
The High and Low Molecular Weight Forms of Hyaluronan Have Distinct Effects on CD44 Clustering*
  • C. Yang, M. Cao, +8 authors F. Gao
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1 November 2012
Background: The feature of CD44 binding with native high molecular weight hyaluronan (nHA) and hyaluronan oligosaccharides (oHA) is different. Results: nHA induces but oHA reduces CD44 clustering.Expand
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Hyaluronan oligosaccharides promote excisional wound healing through enhanced angiogenesis.
  • F. Gao, Yiwen Liu, +4 authors Guo Wei
  • Chemistry, Medicine
  • Matrix biology : journal of the International…
  • 1 March 2010
The biological roles of hyaluronan (HA) fragments in angiogenesis acceleration have been investigated recently. Studies have confirmed that oligosaccharides of HA (o-HA) are capable of stimulatingExpand
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Low Molecular Weight Hyaluronan Induces Lymphangiogenesis through LYVE-1-Mediated Signaling Pathways
Hyaluronan (HA), a large nonsulfated glycosaminogycan in the extracellular matrix, whose degraded fragments termed as low molecular weight hyaluronan (LMW-HA), has been reported as an importantExpand
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A novel role of low molecular weight hyaluronan in breast cancer metastasis
  • M. Wu, M. Cao, +5 authors F. Gao
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1 April 2015
Low molecular weight hyaluronan (LMW‐HA), a degradation fragment of the extracellular matrix component hyaluronan (HA), has been proven to play a crucial role in cancer progression. However, noExpand
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Increased drug resistance in breast cancer by tumor-associated macrophages through IL-10/STAT3/bcl-2 signaling pathway
Tumor-associated macrophages (TAMs) appear to be the major component in solid tumor microenvironment, which were reported to play an important role in tumor malignant progression. Recently, TAMs wereExpand
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Preparation and characterization of hyaluronan oligosaccharides for angiogenesis study.
Low molecular weight hyaluronan (HA) is proved to be active in stimulating endothelial cell (EC) proliferation. The study is to obtain biological active HA fragments of defined length from highExpand
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Inducible formation of leader cells driven by CD44 switching gives rise to collective invasion and metastases in luminal breast carcinomas
Collective invasion into adjacent tissue is a hallmark of luminal breast cancer, and ~20% of these cases eventually undergo metastasis. How less aggressive luminal-like breast cancer transitions toExpand
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Mitochondrial F1Fo-ATP synthase translocates to cell surface in hepatocytes and has high activity in tumor-like acidic and hypoxic environment.
  • Z. Ma, M. Cao, +7 authors F. Gao
  • Biology, Medicine
  • Acta biochimica et biophysica Sinica
  • 1 August 2010
F1Fo-ATP synthase was originally thought to exclusively locate in the inner membrane of the mitochondria. However, recent studies prove the existence of ectopic F1Fo-ATP synthase on the outside ofExpand
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Interplay between Chromatin Remodeling and Epigenetic Changes during Lineage-Specific Commitment to Granzyme B Expression1
The role of chromatin remodeling and histone posttranslational modifications and how they are integrated to control gene expression during the acquisition of cell-specific functions is poorlyExpand
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The influence of hyaluronic acid on vascular endothelial cell proliferation and the relationship with ezrin/merlin expression.
It has been established that hyaluronic acid (HA) glycans (nHA) and oligosaccharide (oHA) exert different effects on the biological function of the vascular endothelial cell (EC), resulting inExpand
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